Publications by authors named "Lorraina Robinson"
Background: Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the CNS. They are not classified as a separate tumor type in the 2021 WHO classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.
View Article and Find Full Text PDFIntroduction: Concurrent primary brain tumors are rare clinical entities, with a prevalence ranging from 0.1 to 0.5% of all diagnosed brain tumors.
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- Papillary tumor of the pineal region (PTPR) is a rare and unique tumor characterized by specific molecular and histopathologic features, with limited prior research on its variations and clinical presentations.
- In a study of 76 confirmed PTPR cases, researchers identified two main methylation groups (PTPR-A and PTPR-B) and further classified PTPR-B into two subtypes (B1 and B2) based on DNA methylation profiles and genomic variations.
- Clinical outcomes revealed that nearly half of the patients experienced tumor progression, with significant differences in outcomes among the identified subtypes, highlighting the tumor's molecular diversity and potential for recurrence.
Article Synopsis
- The study investigates the structural differences in the posterior atlanto-occipital membrane (PAOM) between children with Chiari malformation type I (CM-I) and a control group undergoing surgery for posterior fossa tumors.
- A total of 35 children were analyzed, with findings showing that the PAOM of CM-I patients had significantly higher disorganized architecture, while other factors like fat and collagen content remained similar between groups.
- Additionally, the study found that children with CM-I had a smaller posterior fossa volume compared to controls, indicating potential structural implications of the malformation.