Altered gene expression in human cleidocranial dysplasia dental pulp cells.

Cleidocranial dysplasia (CCD) is an autosomal dominant disorder characterised by defects of bone and tooth development. The dental manifestations in CCD patients include supernumerary teeth, delayed tooth eruption, tooth hypoplasia and absence of cellular cementum formation. This disorder is associated with mutations in the osteoblast-specific transcription factor Runx2.

Treatment planning in the presence of congenitally absent second premolars: a review of the literature.

One of the most common dental anomalies encountered by the pediatric dentist is the congenital absence of second premolars. Once diagnosed, the appropriate treatment necessitates the formulation of a comprehensive treatment plan, which is dependent upon a number of factors. Considerations include: the condition of the deciduous molar, dental and skeletal relationships, dental age of the patient, willingness of the patient to undergo extensive dental treatment and financial considerations.