Publications by authors named "Lori Erickson"
Article Synopsis
- High-grade follicular cell-derived non-anaplastic thyroid carcinomas are rare tumors, particularly in patients under 21, and are more commonly diagnosed in older adults.
- A study focused on 15 patients aged 9-20 revealed various classifications of thyroid carcinoma, including poorly differentiated and differentiated high-grade types, with specific genetic alterations noted, especially in the DICER1 and TP53 genes.
- Immunohistochemistry tests indicated the presence of BRAF V600E mutations and PTEN alterations, highlighting the molecular complexity of these thyroid cancers in younger populations.
Article Synopsis
- - The study evaluated 121 patients with penile squamous cell carcinoma (pSCC) to explore how well different methods identify high-risk human papillomavirus (HPV) status and to analyze its prevalence and impact on patient outcomes.
- - Results showed that 30.6% of patients were high-risk HPV-positive, with a high sensitivity (97.3%) of morphologic evaluation in predicting HPV status; progression was more common in high-risk HPV-negative patients.
- - The findings suggest that HPV status and certain tumor characteristics can influence prognosis, with differentiation levels in HPV-negative tumors and basaloid morphology in HPV-positive cases playing a significant role in patient mortality.
Article Synopsis
- The study investigates the changes in staging criteria for pT2/pT3 penile squamous cell carcinoma (pSCC) and compares the current AJCC criteria with a proposed modified system based on histopathological variables.
- A total of 48 cases were analyzed, showing no significant difference in disease-free survival (DFS) and progression-free survival (PFS) using AJCC criteria, but significant differences emerged using the modified criteria.
- The proposed staging system may enhance prognostication for pT2/pT3 pSCC tumors, but further research is required to validate its effectiveness across different patient populations.
Article Synopsis
- - Critical illness-related corticosteroid insufficiency (CIRCI) in neonates post-congenital heart surgery can lead to serious health issues, including hemodynamic instability, and is linked to higher morbidity and mortality.
- - A study of neonates undergoing cardiac surgery revealed that those diagnosed with CIRCI had a 100% occurrence of the STX1A gene mutation, whereas this mutation was absent in the non-CIRCI group, indicating a potential genetic basis for CIRCI.
- - Additional mutations in genes like RAB6A and ABCA3 were also found in the CIRCI group but not in the non-CIRCI group, suggesting that further investigation into these genetic factors is needed to understand their role in
Background: Despite improvements in survival over time, the mortality rate for infants with single-ventricle heart disease remains high. Infants of low socioeconomic status (SES) are particularly vulnerable. We sought to determine whether use of a novel remote monitoring program, the Cardiac High Acuity Monitoring Program, mitigates differences in outcomes by SES.
View Article and Find Full Text PDF