Using lesion washout volume fraction as a biomarker to improve suspicious breast lesion characterization.

The purpose of this study was to evaluate using lesion washout (WO) volume fraction as a biomarker to improve the characterization of suspicious breast lesions. Study lesions consisted of a total of 60 malignant tumors (BI-RADS 6) and 62 suspicious lesions (BI-RADS 4 or 5). The biopsies of these suspicious lesions resulted in a total of 30 malignant tumors and 32 benign lesions, respectively, yielding a 48.

Disruption of limbic white matter pathways in mild cognitive impairment and Alzheimer's disease: a DTI/FDG-PET study.

Background: Alzheimer's disease (AD) and mild cognitive impairment (MCI) affect the limbic system, causing medial temporal lobe (MTL) atrophy and posterior cingulate cortex (PCC) hypometabolism. Additionally, diffusion tensor imaging (DTI) studies have demonstrated that MCI and AD involve alterations in cerebral white matter (WM) integrity.

Objectives: To test if (1) patients with MCI and AD exhibit decreases in the integrity of limbic WM pathways; (2) disconnection between PCC and MTL, manifested as disruption of the cingulum bundle, contributes to PCC hypometabolism during incipient AD.

Breast MR imaging: applications and pitfalls.

Context: Contrast-enhanced magnetic resonance (MR) imaging provides better detail of the breast than either mammography or ultrasound imaging and can be a valuable adjunct to other imaging techniques, particularly for small lesions, in dense or augmented breasts and for treatment planning.

Objective: To illustrate some common technical problems encountered with MR imaging of the breast and present breast pathologies depicted with MR.

Results: Using a case-study approach, the authors discuss breast MR imaging difficulties related to hardware, software, technologist performance and patient cooperation.