Historical Perspectives on Core-Carrier Gutta-Percha Obturation.

Dr. William Ben Johnson introduced the contemporary use fo core-carrier technology for root canal obturation in the late 1970s. This technology has undergone multiple enhancements since its commercial introduction in the early 1990s and has provided a unique clinical treatment regimen for clinicians globally.

Temporal changes in inflammatory mediator concentrations in an adjuvant model of temporomandibular joint inflammation.

Aims: To determine temporal changes in the concentrations found in the temporomandibular joint (TMJ) and trigeminal ganglion of 3 specific classes of inflammatory mediators commonly linked with conditions of joint inflammation. The intent was to determine whether concentrations of the neuropeptide calcitonin gene-related peptide (CGRP), the neurotrophin nerve growth factor (NGF), and the proinflammatory cytokines interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNF-alpha) are altered in the trigeminal ganglion and TMJ tissues during various stages of adjuvant-induced inflammation of the rat TMJ.

Methods: Adult male rats received bilateral TMJ injection of complete Freund's adjuvant (CFA), while control rats did not receive CFA treatment.