Publications by authors named "Loretta Pearson"
Article Synopsis
- Electronic patient-reported outcomes (ePROs) can enhance cancer patient care, but integrating them into clinical systems poses significant challenges, requiring technical resources, clinician and patient commitment, and institutional support.* -
- The SIMPRO Research Consortium created and implemented eSyM, an ePRO-based symptom management program across six cancer centers, tracking implementation methods and barriers through established frameworks and tools like REDCap.* -
- Out of 226 documented implementation strategies, 64 unique strategies were identified, with universal strategies that were consistently effective focusing on clinical preparation, training, and patient/clinician engagement being seen as particularly impactful.*
Background: Electronic patient-reported outcome (ePRO)-based symptom management improves cancer patients' outcomes. However, implementation of ePROs is challenging, requiring technical resources for integration into clinical systems, substantial buy-in from clinicians and patients, novel workflows to support between-visit symptom management, and institutional investment.
Methods: The SIMPRO Research Consortium developed eSyM, an electronic health record-integrated, ePRO-based symptom management program for medical oncology and surgery patients and deployed it at six cancer centers between August 2019 and April 2022 in a type II hybrid effectiveness-implementation cluster randomized stepped-wedge study.
Study Design: Prospective evaluation of an informational web-based calculator for communicating estimates of personalized treatment outcomes.
Objective: To evaluate the usability, effectiveness in communicating benefits and risks, and impact on decision quality of a calculator tool for patients with intervertebral disc herniations, spinal stenosis, and degenerative spondylolisthesis who are deciding between surgical and nonsurgical treatments.
Summary Of Background Data: The decision to have back surgery is preference-sensitive and warrants shared decision making.
Background: Despite substantial resources devoted to cancer screening nationally, the availability of clinical practice-based systems to support screening guidelines is not known.
Objective: To characterize the prevalence and correlates of practice-based systems to support breast and cervical cancer screening, with a focus on the patient-centered medical home (PCMH).
Design: Web and mail survey of primary care providers conducted in 2014.
Background: Changes to national guidelines for breast and cervical cancer screening have created confusion and controversy for women and their primary care providers.
Objective: To characterize women's primary health care provider attitudes towards screening and changes in practice in response to recent revisions in guidelines for breast and cervical cancer screening.
Design, Setting, Participants: In 2014, we distributed a confidential web and mail survey to 668 women's health care providers affiliated with the four clinical care networks participating in the three PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) consortium breast cancer research centers (385 respondents; response rate 57.
Purpose: To characterize the inter- and intraobserver variability of qualitative, non-disk contour degenerative findings of the lumbar spine at magnetic resonance (MR) imaging.
Materials And Methods: The case accrual method used to perform this institutional review board-approved, HIPAA-compliant retrospective study was the random selection of 111 interpretable MR examination cases of subjects from the Spine Patient Outcomes Research Trial. The subjects were aged 18-87 years (mean, 53 years +/- 16 [standard deviation]).
Study Design: A reliability assessment of standardized magnetic resonance imaging (MRI) interpretations and measurements.
Objective: To determine the intra- and inter-reader reliability of MRI features of lumbar spinal stenosis (SPS), including severity of central, subarticular, and foraminal stenoses, grading of nerve root impingement, and measurements of cross-sectional area of the spinal canal and thecal sac.
Summary Of Background Data: MRI is commonly used to assess patients with spinal stenosis.
Study Design: Assessment of the reliability of standardized magnetic resonance imaging (MRI) interpretations and measurements.
Objective: To determine the intra- and inter-reader reliability of MRI parameters relevant to patients with intervertebral disc herniation (IDH), including disc morphology classification, degree of thecal sac compromise, grading of nerve root impingement, and measurements of cross-sectional area of the spinal canal, thecal sac, and disc fragment.
Summary Of Background Data: MRI is increasingly used to assess patients with sciatica and IDH, but the relationship between specific imaging characteristics and patient outcomes remains uncertain.
Context: Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine.
Objective: To assess the safety and efficacy of folic acid supplementation for preventing colorectal adenomas.
Design, Setting, And Participants: A double-blind, placebo-controlled, 2-factor, phase 3, randomized clinical trial conducted at 9 clinical centers between July 6, 1994, and October 1, 2004.
The association of physical activity and body mass index with the risk of large bowel polyps.
Cancer Epidemiol Biomarkers Prev
September 2005
Purpose And Method: Several studies have suggested that physical inactivity and obesity increase the risk for colorectal neoplasia. In this study, we investigated the association of physical activity and body mass index (BMI) with the risk of different types of large bowel polyps. We did an observational analysis nested within a randomized double-blind placebo-controlled chemoprevention trial among patients with one or more recently resected histologically confirmed colorectal adenoma.
View Article and Find Full Text PDFBackground: Clinical trials have shown that calcium supplementation modestly decreases the risk of colorectal adenomas. However, few studies have examined the effect of calcium on the risk of different types of colorectal lesions or dietary determinants of this effect.
Methods: Our analysis used patients from the Calcium Polyp Prevention Study, a randomized, double-blind, placebo-controlled chemoprevention trial among patients with a recent colorectal adenoma.
Background: Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel.
Methods: We performed a randomized, double-blind trial of aspirin as a chemopreventive agent against colorectal adenomas. We randomly assigned 1121 patients with a recent history of histologically documented adenomas to receive placebo (372 patients), 81 mg of aspirin (377 patients), or 325 mg of aspirin (372 patients) daily.