Publications by authors named "Lorenzo Socias-Crespi"
Article Synopsis
- Recent studies showed that taking too much venlafaxine (a medication) can lead to low blood sugar, or hypoglycemia, depending on how much is taken.
- In a study of 21 patients in the Balearic Islands, 8 of them had low blood sugar after an overdose, and those with low blood sugar had much higher levels of the drug in their system.
- Low blood sugar was linked to younger age, less alertness, and more serious health problems like seizures and needing to be treated in the ICU.
Background: Ventilator-associated pneumonia (VAP) represents a transitory status of immunoparalysis, and we hypothesized that ventilator-associated tracheobronchitis (VAT) could share also some degree of immune response to a respiratory infection.
Research Design And Methods: A prospective observational study in five medical ICUs to evaluate immunological alterations of patients with VA-LRTI. Immunological gene expression profiles in the blood using whole transcriptome microarrays in the first 24 hours following diagnosis.
Objective: To design a mortality indicator in acute coronary syndrome (ACS) in the intensive care unit (ICU).
Design: A multicenter, observational descriptive study was carried out.
Participants: Patients with ACS admitted to the ICUs included in the ARIAM-SEMICYUC registry between January 2013 and April 2019.
Introduction: Bronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.
Aim: To identify the proteomic determinants associated with disease pathogenesis, all-cause mortality and respiratory sequelae in BAS samples from critically ill patients with SARS-CoV-2-induced ARDS.
Methods: Multicenter study including 74 critically ill patients with COVID-19 and non-COVID-19 ARDS.
Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and uninfected control patients and characterized the effects and cohort frequency of ACE2 SNPs.
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- The study aimed to evaluate the impact of corticosteroids on ICU mortality in mechanically ventilated COVID-19 patients suffering from ARDS.
- Conducted in 70 ICUs, the study included 1,835 patients, with 1,117 receiving corticosteroids; however, initial results showed no significant difference in ICU mortality between those treated and those untreated with corticosteroids.
- While corticosteroid treatment appeared to provide short-term survival benefits, it led to increased ICU mortality after 17 days, particularly benefiting younger patients and those with severe ARDS.
Introduction And Objectives: Sudden cardiac death (SCD) in young people often has a genetic cause. Consequently, the results of "molecular autopsy" may have important implications for their relatives. Our objective was to evaluate the diagnostic yield of a molecular autopsy program using next-generation sequencing.
View Article and Find Full Text PDFAmphetamine and methamphetamine poisonings attended in hospital emergency departments: clinical features and the usefulness of laboratory confirmation.
Emergencias
February 2020
Objectives: To determine whether clinical and toxicologic findings differed between cases of amphetamine (AMP) and methamphetamine (mAMP) poisoning attended in 2 Balearic Island hospital emergency departments.
Material And Methods: Retrospective observational study of AMP and mAMP cases with laboratory confirmation between 2013 and 2018. We compared clinical and toxicologic variables as well as clinical management between groups.
Objective: We wished to explore the use, diagnostic capability and outcomes of bronchoscopy added to noninvasive testing in immunocompromised patients. In this setting, an inability to identify the cause of acute hypoxaemic respiratory failure is associated with worse outcome. Every effort should be made to obtain a diagnosis, either with noninvasive testing alone or combined with bronchoscopy.
View Article and Find Full Text PDFIntroduction: Caspofungin is an echinocandin with proven efficacy in invasive candidiasis (IC) and invasive aspergillosis (IA). ProCAS is a study sponsored by the Working Group of the Infectious Diseases of the Spanish Society of Intensive Care Medicine, which analyzes the effectiveness and safety of caspofungin in routine clinical practice conditions in the critically ill.
Methods: A prospective, multicenter, observational study designed to estimate the clinical effectiveness and safety of caspofungin acetate in the treatment of IC and IA in patients refractory to or intolerant of conventional antifungal therapy.