Publications by authors named "Lorenzo R Cruz"

Article Synopsis
  • The study focuses on identifying predictive biomarkers for hepatocellular carcinoma (HCC) related to metabolic dysfunction-associated steatotic liver disease (MASLD) by examining the gut microbiome and liver gene expression in mice with altered Pten genes.
  • Findings reveal that changes in gut microbiome composition correlate with tumor presence, particularly in mice with multiple tumors, while specific gene expression changes in the liver are linked to tumor burden and inflammation.
  • The research uncovers potential microbiome factors and gene expression patterns that drive liver cancer development, which could aid in creating new prevention strategies and risk assessment tools for HCC.
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Mexican Americans are disproportionally affected by metabolic dysfunction-associated steatotic liver disease (MASLD), which often co-occurs with diabetes. Despite extensive evidence on the causative role of the gut microbiome in MASLD, studies determining the involvement of the gut phageome are scarce. In this cross-sectional study, we characterized the gut phageome in Mexican Americans of South Texas by stool shotgun metagenomic sequencing of 340 subjects, concurrently screened for liver steatosis by transient elastography.

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Pentalogy of Cantrell is a rare disease. Approximately 185 cases have been reported around the world. The authors performed a retrospective study that reviewed the clinical files and pathological samples of 22 cases of pentalogy of Cantrell treated at the Hospital Infantil de México Federico Gómez.

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Objective: To evaluate the effect of carvedilol administrated during 8 months in children with heart failure secondary to dilated cardiomyopathy.

Methods: We initiated carvedilol in patients who, despite optimization of standard treatment, had persistent left ventricular ejection fraction < or = 40% and evaluated the systolic and diastolic left ventricular function before and after 4 and 8 months of treatment.

Results: 19 patients were included in the study, 10 women; median age: 6.

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