Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study.

Background: A dose-finding study was performed as the first step in the clinical development of the new drug, cizolirtine citrate.

Objective: To assess the efficacy and safety of cizolirtine citrate in overactive bladder with urinary incontinence.

Design, Setting, And Participants: Seventy-nine outpatients with clinical overactive bladder and/or urodynamic diagnosis of detrusor overactivity were randomized in a multicentre, 12-wk, double-blind, pilot trial.