Publications by authors named "Lorenzo Nescis"
A deadly embrace occurs between cancer and chronic kidney disease. The estimation of kidney function in cancer patients is of utmost interest due to its direct impact on chemotherapy dosing, selection, and eligibility for chemotherapeutics. Overestimating kidney function (determined as estimated glomerular filtration rate -eGFR) can lead to overdosing and drug toxicity, while underestimating kidney function can prevent patients from receiving novel therapies.
View Article and Find Full Text PDFPregnant women are at high risk of Coronavirus disease 2019 (COVID-19) complications, including acute respiratory distress syndrome. Currently, one of the cornerstones in the treatment of this condition is lung-protective ventilation (LPV) with low tidal volumes. However, the occurrence of hypercapnia may limit this ventilatory strategy.
View Article and Find Full Text PDFLung-protective ventilation (LPV) with low tidal volumes can significantly increase the survival of patients with acute respiratory distress syndrome (ARDS) by limiting ventilator-induced lung injuries. However, one of the main concerns regarding the use of LPV is the risk of developing hypercapnia and respiratory acidosis, which may limit the clinical application of this strategy. This is the reason why different extracorporeal CO removal (ECCOR) techniques and devices have been developed.
View Article and Find Full Text PDFArticle Synopsis
- FOXP3 is a key transcription factor for regulatory T cells, and mutations in this gene can cause an X-linked syndrome called IPEX, characterized by symptoms like severe diarrhea, diabetes, and eczema.
- The study presents two unique cases of patients with rare associations to IPEX, involving inflammatory and kidney issues identified through advanced genetic screening.
- Both patients exhibited atypical symptoms: one with autoimmune lymphoproliferative syndrome and kidney problems, and the other with bone marrow failure leading to IgG4-related kidney disease, highlighting the need to recognize these conditions as part of IPEX's clinical spectrum.