Publications by authors named "Lorenzo Morante"
Biologic graft infection (BGI) is one of the main complications in graft reconstructions. However, very little evidence exists regarding the epidemiology of BGI, as most of the data come from sparse reports. Moreover, most of the series did not detail the treatment and outcome of graft infections.
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- Periprosthetic joint infections (PJI) and fracture-related infections (FRI) of the distal femur can lead to significant bone loss, and a two-stage treatment protocol utilizing articulated silver-coated megaprosthesis was studied.
- A review of three institutions included 45 patients, showing an estimated 91.1% survival rate free from recurrence of infection two years after surgery, with complications primarily involving non-infection-related issues.
- Significant findings indicated that a longer resection length negatively impacted infection control, while the initial diagnosis (PJI or FRI) did not significantly affect outcomes, affirming the safety and effectiveness of this treatment approach.
Modular megaprostheses (MPs) are commonly used after bone-tumor resection, but they can offer a limb salvage solution in massive bone defects. The aim of this systematic review of the Literature is to provide a comprehensive data collection concerning the use of MPs in non-oncologic cases, and to provide an overview of this topic, especially from an epidemiologic point of view. Three different databases (PubMed, Scopus, and Web of Science) were searched for relevant articles, and further references were obtained by cross-referencing.
View Article and Find Full Text PDFPurpose: A staged revision with placement of a temporary antibiotic-loaded cement spacer after removal of the implant is the "gold standard" for treatment of chronic prosthetic joint infection (PJI). It enables local delivery of antibiotics, maintenance of limb-length and mobility, easier reimplantation. However, bacterial colonization of spacers and mechanical complications can also occur.
View Article and Find Full Text PDFIn the treatment of knee periprosthetic joint infection with a two-stage protocol, static spacers allow for the local delivery of high doses of antibiotics and help to preserve soft tissue tension. Articulated spacers were introduced to better preserve flexion after the reimplantation. The aim of this systematic review is to provide a comprehensive data collection of the results of these different spacers.
View Article and Find Full Text PDFProsthetic joint infections (PJIs) occurring in multiple joints at the same time (synchronous PJI) are an extremely rare complication, frequently associated with bacteremia, and are associated with high mortality rates. The presence of three or more prosthetic joints, rheumatoid arthritis, neoplasia, bacteremia and immune-modulating therapy seem to be the recurring risk factors for synchronous PJI. In case of PJIs, all other replaced joints should be considered as potentially infected and investigated if PJI is suspected.
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- * Most current research is still in preclinical stages, with limited studies including lab experiments, animal models, and some in vitro and in vivo analyses.
- * Preliminary findings suggest that silver enhances antibacterial activity in bone substitutes, but more research is needed to understand its effectiveness and safety in clinical applications.
Introduction: Temporary spacers used in the staged revision of a hip prosthetic joint infection (PJI) have been associated with several mechanical complications with very variable reported general complications rates up to 73%. The aim of this systematic review was to assess the mechanical complications associated with hip antibiotic-loaded spacers when treating periprosthetic hip PJI.
Methods: Through an electronic systematic search of PubMed, articles reporting mechanical complications of spacers used in the treatment of hip PJI were reviewed.