Differential changes in expression of inflammatory mRNA and protein after oleic acid-induced acute lung injury.

Acute Respiratory Distress syndrome (ARDS) is a clinical syndrome of noncardiac pulmonary edema and inflammation leading to acute respiratory failure. We used the oleic acid infusion pig model of ARDS resembling human disease to explore cytokine changes in white blood cells (WBC) and plasma proteins, comparing baseline to ARDS values. Nineteen juvenile female swine were included in the study.

Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model.

Purpose: To investigate the correlation between volume of carbon dioxide elimination (V̇CO) and end-tidal carbon dioxide (PETCO) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model.

Methods: Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using oleic acid infusion.

Results: Prior to ARDS induction, mean (SD) CO, V̇CO, PETCO, and dead space to tidal volume ratio (V/V) were 4.