Reassessment of the polar fraction of (L.) Benth. subsp. (Ten.) Grande (Lamiaceae) from the Monti Sibillini National Park: A potential source of bioactive compounds.

Background: The phytochemical analysis of subsp. , an endemic Italian species, has been recently reported and has showed the presence of 8-O-acetylharpagide (2), harpagide (3), allobetonicoside (4), and 4¢-O-galactopyranosyl-teuhircoside (5). In this paper, an in deep study of its glycosidic fraction with the aim to widen the knowledge on its secondary metabolites content is reported.

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island.

The phytochemical analysis of the ethanolic extract obtained from D. oleoides collected from Sardinia Island allowed the isolation of several new constituents for the species (3, 8, and 9) together with two new coumarinyl ethers (1 and 2) besides the chemotaxonomic markers of the Daphne genus (4 - 7 and 10) which are also known to possess interesting biological activities. The structure of the new compounds were elucidated by extensive spectroscopic and spectrometric analyses.