Mitochondrial Dysfunction in Parkinson's Disease: A Contribution to Cognitive Impairment?

Among the non-motor symptoms associated with Parkinson's disease (PD), cognitive impairment is one of the most common and disabling. It can occur either early or late during the disease, and it is heterogeneous in terms of its clinical manifestations, such as Subjective Cognitive Dysfunction (SCD), Mild Cognitive Impairment (MCI), and Parkinson's Disease Dementia (PDD). The aim of the present review is to delve deeper into the molecular mechanisms underlying cognitive decline in PD.

Life on a hilltop: vegetation history, plant husbandry and pastoralism at the dawn of Bergamo-Bergomum (northern Italy, 15th to 7th century bc).

Cores and trenches drilled or dug in religious and secular buildings in the hilltop town of Bergamo (northern Italy) were investigated by means of micro/macrobotanical and pedochemical analysis to unravel the cultural vegetation history of the area during ca. seven centuries across the Bronze-Iron Ages. We explore the predictive power of biological proxies, nutrients, and coupled C datings to reveal early phases of human settlement and activity in a modern urban context with low visibility and difficult accessibility.