Primin sensitization in north-eastern Italy: a temporal trend from 1996 to 2012.

Background: Primin is the main contact allergen found in the ornamental plant Primula obconica Hance.

Objective: To analyse the temporal trend of sensitivity to primin in north-eastern Italy and to evaluate the associations with occupations in our geographical area.

Methodology: From 1996 to 2012, 24 052 consecutive patients with suspected allergic contact dermatitis were patch tested in north-eastern Italy.

[Major and minor amputation rates and lower critical limb ischemia: the epidemiological data of western Tuscany].

Background: The aim of this study was to evaluate the incidence of major amputations and critical limb ischemia in an unselected population of western Tuscany.

Methods: Out of an overall 1234000 people living in Pisa and surroundings (western Tuscany), a total amount of 306 patients underwent 319 different major/minor amputations during the year 2002 in private and public hospitals, both in Tuscany and in other regions.

Results: 84.