Publications by authors named "Lorenzo Bean"

Article Synopsis
  • - Fanconi anaemia (FA) is a genetic condition that makes DNA repair faulty, leading to chromosome breakage and a significantly higher risk of specific cancers such as head and neck, esophageal, and anogenital squamous cell carcinomas compared to the general population.
  • - Research reveals that squamous cell carcinomas from FA patients exhibit numerous structural variants, which include small deletions and complex rearrangements, often occurring alongside loss of the TP53 gene but not related to HPV infections.
  • - The instability caused by FA may trigger processes like epithelial-to-mesenchymal transition and heightened inflammatory signaling in skin cells, highlighting the potential for FA's unique genomic issues to inform understanding of sporadic HNSCC linked to tobacco and alcohol
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Background: It is not known whether an intervention using real-time provider teaching in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) improves provider knowledge and/or patient outcomes.

Objective: To pilot the combination of a novel, real-time provider teaching intervention delivered by subspecialists to Internal Medicine trainees with a traditional patient education and medication reconciliation (PEMR) intervention and to assess the impact of these interventions on provider knowledge regarding COPD and patient care.

Methods: This was a single-center, nonrandomized, quality-improvement study.

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Background: Intra-abdominal abscesses are localized collections of pus, which generally arise from a breach in the normal mucosal defense barrier that allows bacteria from gastrointestinal tract, and less commonly from the gynecologic or urinary tract, to induce inflammation, resulting in an infection. The microbiology of these abscesses is usually polymicrobial, associated with the primary disease process. However, the microbial identity, diversity and richness in intra-abdominal abscesses have not been well characterized, due in part to the difficulty in cultivating commensal organisms using standard culture-based techniques.

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