Publications by authors named "Lorenzo Agostini"
Background: In Italy, longstanding limitations in the existing reporting system of the inpatient rehabilitation activities have been reported. The Hospital Discharge form (HDF) primarily uses ICD codes that inadequately capture the functional status and rehabilitation needs of patients, impacting equity of care and service evaluation. Therefore, the Italian Ministry of Health (IMH) launched an initiative aimed at developing a new reporting system to be specifically adopted in the inpatient rehabilitation setting.
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- SARS-CoV-2, the virus causing COVID-19, affects the body by interacting with host-cell receptors via its spike protein (S protein).
- The study reveals that the S protein triggers significant changes in platelets, which can lead to their permanent activation, a factor contributing to coagulopathies in COVID-19 patients.
- Researchers found that the S protein binds to specific platelet integrins that induce filopodia formation, suggesting that these interactions play a role in the disease's severity and blood clotting complications.
Article Synopsis
- SARS-CoV-2, the virus causing COVID-19, interacts with host-cell receptors through its spike protein, which is crucial for its high pathogenicity.
- The study reveals that the spike protein can cause platelets to deform and activate irreversibly, suggesting a direct link between the virus and coagulopathies in COVID-19 patients.
- Researchers found that the spike protein binds to specific integrin receptors on platelets, indicating that this interaction may play a role in the severe coagulation issues associated with COVID-19.
Endobronchial Ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is usually performed under general anesthesia or deep sedation with drugs such as Propofol that, at least in Italy, can be administered only by an anesthesiologist. Aim of the study was to assess conscious sedation feasibility, safety and tolerability using Meperidine and Midazolam as administered by Pulmonologist and relevant impact on the efficiency of the sampling procedures.All patients undergoing EBUS-TBNA from February 2013 to July 2014 were examined retrospectively.
View Article and Find Full Text PDFBackground And Aims: Bronchial fibroepithelial polyp is an uncommon, poorly recognised lesion, lacking clear diagnostic criteria at histology, but possibly mimicking neoplastic growth on clinico-radiologic and histopathological grounds. The aim of this study was to define the clinico-pathological features, bronchoscopic appearance and treatment of bronchial fibroepithelial polyp.
Methods: We collected the largest series of bronchial fibroepithelial polyps (15 consecutive cases), including clinico-pathological, bronchoscopic, radiologic and histological features.
Purpose: Endobronchial metastases from extrapulmonary solid tumors are a rare event and currently available epidemiological and clinico-pathological data mainly derive from anecdotal case reports.
Methods: A series of 174 consecutive cases of endobronchial metastases from extrathoracic solid tumors were collected over a period of 18 years. Immunohistochemistry was performed in 115 cases.
The acquisition of histologic material is obligatory in order to establish the diagnosis of malignant pleural mesothelioma (MPM). In particular, tissue acquisition in cases of "dry" MPM (focal pleural thickening without pleural effusion or mediastinal lymph node involvement) is usually performed via a thoracoscopic pleural biopsy. In contrast, the techniques for performing echoendoscopic (transbronchial or transesophageal) needle aspiration of pleural lesions have only rarely been reported due to the theoretical limitations of tissue acquisition in such cases.
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