Publications by authors named "Lorenza O D'Onofrio"
Article Synopsis
- Hyperhomocysteinemia is linked to a higher risk of coronary artery disease (CAD), and a specific mutation in the MTHFR gene (C677T) contributes to this by causing mild hyperhomocysteinemia.
- A study involving 772 individuals (Caucasian and African Brazilians) found a significantly higher frequency of the 677T allele in Caucasian Brazilians, who also showed an association between the homozygous genotype and CAD in males.
- The research indicates that the C677T MTHFR mutation is a significant predictor of CAD risk, particularly among males, highlighting the need to consider sex and ethnicity in assessing cardiovascular risks.
Background: Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation.
Methods: We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who underwent coronary angiography.
Results: Among Caucasian-Brazilians, the homozygous 55LeuLeu frequency was higher among patients with significant coronary artery disease (CAD, obstructive lesions >/=50%) than among lesion-free controls (51% vs.
The nitric oxide produced by endothelial nitric oxide synthase (eNOS) plays a pivotal role in protecting the arterial wall from damages and atherosclerosis. The T-786C, the 27-bp repeat in intron 4, and the E298D eNOS gene polymorphisms were studied in 715 Brazilian patients (447 Caucasian- and 268 African-Brazilians) who underwent coronary angiography. The -786C frequency was increased in coronary artery disease (CAD) cases with significant lesions (> or =50% luminal obstruction) when compared with lesion-free controls; this difference was detected in smokers but not in nonsmokers, both in Caucasian- (p=0.
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