Breakthrough COVID-19 in people with multiple sclerosis on disease modifying treatments: Is it still a severe disease?

Introduction: Disease modifying treatments (DMTs) for multiple sclerosis (MS) are effective in preventing both relapses and disability progression. Highly effective treatments (HETs) are more effective than platform therapy in preventing confirmed disability progression (CDP), when used early. Infections may complicate HETs administration, and their prevention through vaccination is crucial in order to assure the safety of people with MS (pwMS).

The Impact of Highly Effective Treatment in Pediatric-Onset Multiple Sclerosis: A Case Series.

Introduction: Pediatric-onset multiple sclerosis (POMS) is characterized by high inflammatory disease activity. Our aim was to describe the treatment sequencing and report the impact highly effective disease-modifying treatment (HET) had on disease activity.

Materials And Methods: Five consecutive patients with POMS were administered HET following lower efficacy drug or as initial therapy.