Optimized communication during risk disclosure to reduce nocebo headache after lumbar puncture-a study protocol for a randomized controlled clinical trial.

Risk communication has been found to be a driver of nocebo effects in medical settings by enhancing negative expectations. In fact, merely disclosing the risk of side effects and complications of treatments or medical procedures increases reports of adverse events. Along these lines, it has been proposed that the occurrence of headache after lumbar puncture (LP), a routine diagnostic procedure in neurology, is caused to a large degree by the information delivered by the physician during the informed consent procedure.

Familial adult myoclonic epilepsy (FAME): clinical features, molecular characteristics, pathophysiological aspects and diagnostic work-up.

Familial adult myoclonic epilepsy (FAME) is a rare autosomal dominant disorder characterized by myoclonus and seizures. The genetic variant underlying FAME is an intronic repeat expansion composed of two different pentamers: an expanded TTTTA, which is the motif originally present at the locus, and an insertion of TTTCA repeats, which is usually located at the 3' end and likely corresponds to the pathogenic part of the expansion. This repeat expansion has been identified so far in six genes located on different chromosomes, which remarkably encode proteins with distinct cellular localizations and functions.

Neurological examination course in an interactive webinar as a solution during a pandemic. An overview of the implementation, optimization as well as critical considerations.

The COVID-19 pandemic made the traditional bedside teaching inaccessible for medical students. Within a short period of time, established bedside teaching concepts had to be converted into online formats to meet the requirements of the health authorities. The Department of Neurology at the University Hospital Essen transformed the examination course in the 5 clinical semester into a live stream, taking into account data protection guidelines.