Publications by authors named "Lorena Pareja Gutierrez"
Objective: The COVID-19 pandemic affected neuro-oncological patients and their caregivers regarding tumor care and emotional functioning, including Quality of Life (QoL). This study aimed to understand how COVID-19 affected their psychological state and the relations between patients and health personnel in neuro-oncology.
Methods: A cross-sectional study was conducted on neuro-oncological patients and their caregivers.
Cladribine vs other drugs in MS: Merging randomized trial with real-life data.
Neurol Neuroimmunol Neuroinflamm
November 2020
Objective: Cladribine tablets were tested against placebo in randomized controlled trials (RCTs). In this study, the effectiveness of cladribine vs other approved drugs in patients with relapsing-remitting MS (RRMS) was compared by matching RCT to observational data.
Methods: Data from the pivotal trial assessing cladribine tablets vs placebo (CLARITY) were propensity score matched to data from the Italian multicenter database i-MuST.
Article Synopsis
- The study investigated factors influencing the initial treatment choice for newly diagnosed relapsing-remitting Multiple Sclerosis (MS) patients in Italy, involving data from 2010 to 2018.
- Key determinants included recent relapses, spinal cord lesions, and a higher number of MRI lesions impacting the choice between dimethyl fumarate and injectable drugs.
- Findings indicated a trend towards selecting oral therapies like dimethyl fumarate and teriflunomide over injectables in recent years, with age, gender, and disease severity influencing the choice of specific medications.
Background: With many options now available, first therapy choice is challenging in multiple sclerosis (MS) and depends mainly on neurologist and patient preferences.
Objectives: To identify prognostic factors for early switch after first therapy choice.
Methods: Newly diagnosed relapsing-remitting MS patients from 24 Italian centers were included.
Objective: To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS).
Methods: Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BDI-II) and State/Trait Anxiety Inventory (STAI-Y). The inflammatory activity level was assessed by MRI.
Background: Sympathovagal imbalance has been associated with poor prognosis in chronic diseases, but there is conflicting evidence in multiple sclerosis.
Objectives: The objective of this study was to investigate the autonomic nervous system dysfunction correlation with inflammation and progression in multiple sclerosis.
Methods: Heart rate variability was analysed in 120 multiple sclerosis patients and 60 healthy controls during supine rest and head-up tilt test; the normalised units of low frequency and high frequency power were considered to assess sympathetic and vagal components, respectively.