Cardiovascular risk factors across different levels of urbanization in Brazilian Afro-derived communities (quilombos).

Objectives: The frequency of cardiovascular diseases has increased throughout the world. People of African descent have been disproportionately affected, particularly if they reside in urban settings. In this work, we evaluate risk factors associated with cardiovascular diseases (CVD) and other chronic diseases in rural and urban Afro-derived communities (quilombo) in Central Brazil.

Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.

Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle.

The distribution in native populations from Mexico and Central America of the C677T variant in the MTHFR gene.

Objectives: To explore evolutionary hypotheses for the high frequencies of a substitution in the methylenetetrahydrofolate reductase (MTHFR) gene, in Mexican and Central American Indigenous populations.

Materials And Methods: We obtained allele frequencies for the C677T variant in the MTHFR gene and ecological information for 37 indigenous samples from Mexico and Central America. We calculated Hardy-Weinberg equilibrium and computed Fst statistics.

Early maturity, shortened stature, and hardship: Can life-history trade-offs indicate social stratification and income inequality in the United States?

Objective: Life-history strategies promote reproductive fitness and survival. Limited energy availability and competing energetic demands between life-history decisions may result in organismal trade-offs leading to selection for "optimal" traits that facilitate fitness and survival in present environmental conditions. Few life-history analyses have been conducted in food abundant/high resource human populations.

Fetal Hemoglobin Modulators May Be Associated With Symptomology of Football Players with Sickle Cell Trait.

Objectives: This study investigates whether genetic modifiers previously shown to influence adult fetal hemoglobin (HbF) levels and glucose-6-phosphate dehydrogenase deficiency were associated with variable symptomology in a small sample of collegiate football players with sickle cell trait.

Methods: Survey data on self-assessed symptoms and genotype data from five single nucleotide polymorphisms (SNPs) related to HbF production and two SNPs that cause glucose-6-phosphate dehydrogenase deficiency were collected from current and former college football players.

Results: In this sample, SNPs found within the β-globin gene cluster were found to be associated with a previous diagnosis of exertional sickling and experience of extreme heat during and after training.

A mitochondrial haplogroup is associated with decreased longevity in a historic new world population.

Interest in mitochondrial influences on extended longevity has been mounting, as evidenced by a growing literature. Such work has demonstrated that some haplogroups are associated with increased longevity and that such associations are population specific. Most previous work, however, suffers from the methodological shortcoming that long-lived individuals are compared with "controls" who are born decades after the aged individuals.

Women who deliver twins are more likely to smoke and have high frequencies of specific SNPs: Results from a sample of African-American women who delivered preterm, low birth weight babies.

Objectives: We examine if there are genetic and environmental differences between mothers of singleton and multiple pregnancies in a sample of African-American mothers.

Methods: We focus on genomic areas suggested to increase or decrease the odds of multiple pregnancies. We computed the odds ratio (OR) and the 95% confidence interval (CI) for each SNP unadjusted or adjusted with smoking.

High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees.

Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial DNA vary widely, depending on whether they are inferred from phylogenies (assuming that molecular evolution is clock-like) or directly from pedigrees. All pedigree-based studies so far were conducted on populations of European origin. In this article, we analyzed 19 deep-rooting pedigrees in a population of mixed origin in Costa Rica.

Obesity, hypertension, and migration: a meta-analysis of populations of the South Asian diaspora.

The effects of migration on human health have been a topic of interest for demographers and human biologists. Even if migrants to a new region achieve a higher standard of living in their new place of residence, their improved living conditions may not be associated with better health. Part of the difficulty of understanding the health consequences of migration is the complications in trying to control for variables that may affect health, such as gender, age, and urban or rural environment of migrants and nonmigrants.

Mitochondrial polymorphisms associated with differential longevity do not impact lifetime-reproductive success.

Objective: To determine if individuals who carry mitochondrial markers which have been previously shown to affect longevity also have differential lifetime reproductive success (LRS).

Methods: We extracted the mtDNA from living subjects residing in Atenas, Costa Rica. Since mtDNA does not recombine, and its probability of mutation is low, we assume that all maternal ancestors of the living subjects have the same mtDNA.

Mitochondrial polymorphisms are associated both with increased and decreased longevity.

Previous work compared frequency of longevity-associated polymorphisms (LAPS) in long-lived individuals and in controls from the general population (primarily in Europe and Japan), suggesting the polymorphisms are responsible for unusual longevity. However, individuals from the general population are not the control group for long-lived subjects because both were born in different periods. We report results of a project which collected mtDNA from living subjects in Costa Rica, and traced back their maternal genealogy.

[Inulin and derivates as key ingredients in functional foods].

Inulin is a non-digestible carbohydrate that is contained in many vegetables, fruits and cereals. It is industrially produced from the chicory's root (Cichorium intybus) and it is widely used as ingredient in functional foods. Inulin and its derivate compounds (oligofructose, fructooligosaccharides) are usually called fructans, as they are basically based on linear fructose chains.

Grandmothers' longevity negatively affects daughters' fertility.

The evolution of postmenopausal longevity in human females has been the subject of debate. Specifically, there is disagreement about whether the evolution of the trait should be understood as an adaptive or a neutral process, and if the former, what the selective mechanism is. There are two main adaptive proposals to explain the evolution of postreproductive longevity: the grandmother and the mother hypotheses.

Indentured migration and differential gender gene flow: the origin and evolution of the East-Indian community of Limón, Costa Rica.

After the emancipation of African slaves in the Caribbean, the labor void left by out-migrating former slaves was filled by in-migrating indentured servants from prepartition India and China. In some areas of the Caribbean such as Trinidad, Suriname, and Guyana, the East-Indian migrants formed large communities. In this article, we report a study based on mtDNA and Y-chromosomal markers of a small East-Indian community from Limón, Costa Rica.

Human skin-color sexual dimorphism: a test of the sexual selection hypothesis.

Applied to skin color, the sexual selection hypothesis proposes that male preference for light-skinned females explains the presence of light skin in areas of low solar radiation. According to this proposal, in areas of high solar radiation, natural selection for dark skin overrides the universal preference of males for light females. But in areas in which natural selection ceases to act, sexual selection becomes more important, and causes human populations to become light-skinned, and females to be lighter than males.

Heritability and anthropometric influences on human fertility.

This study researched the impact of anthropometrics and size-of-family of orientation on women's fertility by using path analysis. The data were collected as part of the anthropological study conducted in Ireland by Harvard University personnel before the Second World War. The women included in this analysis were all over age 49 and were either married or widowed at the time of the survey.

Menarcheal age and spontaneous abortion: Further evidence for a connection.

This paper examines the association between menarcheal age and risk of spontaneous abortion with a data set collected in Limon, Costa Rica. The Limonense sample differs from those previously reported in terms of age, socioeconomic and ethnic background. Thus, the sample is excellent to test whether menarcheal age and risk of miscarriage are associated in a nonindustrialized group as they appear to be in industrialized samples.

The reliability of recalled estimates of menarcheal age in a sample of older women.

The accuracy of recalled age at first menses has been questioned, particularly if subjects are relatively old. This paper illustrates the use of a statistical technique that quantifies the reliability of recalled age at menarche based on re-interview of a small (15-20) subsample of subjects. Menarcheal age collected with the retrospective method in a sample of 108 females, 50 years of age and older, from Limón, Costa Rica, is reliable.