Publications by authors named "Lorena Cuenca"
Article Synopsis
- Sleep deprivation leads to memory issues similar to those seen in dementia and is associated with stress-induced hormone changes, like elevated cortisol levels.
- The study used the Octodon degus rodent model to explore how stress, exercise, and age affect memory after sleep deprivation.
- Findings showed that while sleep deprivation impaired memory in both young and aged rodents, voluntary exercise improved cognitive performance and reduced cortisol levels regardless of age.
Article Synopsis
- Recent studies suggest brain and peripheral inflammation contribute to the progression of Parkinson's disease, but the exact causes remain unclear.
- This research examines how acute inflammation in the colon affects dopaminergic neuron death and glial responses in mice exposed to a neurotoxin (MPTP).
- Findings indicate that colonic inflammation exacerbates neuron loss and activates glial cells, highlighting a potential link between gastrointestinal issues and the worsening of Parkinson's symptoms.
Article Synopsis
- The study explores the potential of using a combination of anti-inflammatory and antioxidant drugs to slow down neurodegenerative disorders, particularly focusing on Parkinson's disease (PD) in older mice.
- Researchers found that the combination of N-acetylcysteine (NAC) and HA-1077 led to increased neuronal death and heightened neuroinflammatory responses in the brains of aged mice exposed to a Parkinson's disease model.
- These unexpected toxic effects emphasize the need for caution when prescribing drug combinations to elderly patients with Parkinson's, as they may worsen the disease rather than help it.
Article Synopsis
- This study investigates the combined effects of physical activity and N-acetyl-L-cysteine (NAC) on dopaminergic cell death and inflammation in a mouse model of Parkinson's disease induced by MPTP.
- The research involved 48 male mice, which were monitored for voluntary physical activity over 30 days and divided into four groups: control, NAC, MPTP, and MPTP+NAC.
- Results showed that while physical activity was generally increased, it did not protect dopaminergic neurons, as marked reductions in neuron numbers were found in all MPTP-treated groups, indicating that the combination of PA and NAC failed to mitigate neurodegenerative effects.
Introduction: Raltegravir (RAL) is the first in class integrase inhibitor and is licensed for administration at 400 mg twice daily. RAL pharmacokinetics are characterized by high interpatient variability and recently RAL plasma exposure has been correlated with efficacy. RAL is primarily metabolized by glucuronidation via uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) and UGT1A1*28 considered to be the main genetic variant associated with decreased UGT1A1 expression.
View Article and Find Full Text PDFGiven that atazanavir (ATV) increases bilirubin in an exposure-dependent manner, we tested whether bilirubin levels could be used as a surrogate of virological response to ATV-based regimens in 182 patients. Bilirubin increases of ≥0.7 mg/dl were independently associated with early virological response with an odds ratio of 5.
View Article and Find Full Text PDFAtazanavir (ATV) plasma concentrations are influenced by CYP3A4 and ABCB1, which are regulated by the pregnane X receptor (PXR; NR1I2). PXR expression is correlated with CYP3A4 in liver in the absence of enzyme inducers. The PXR single nucleotide polymorphism (SNP) 63396C→T (rs2472677) alters PXR expression and CYP3A4 activity in vitro, and we previously showed an association of this polymorphism with unboosted ATV plasma concentrations.
View Article and Find Full Text PDFThe equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Polymorphisms at the ENT1 gene may influence ribavirin activity as part of hepatitis C virus (HCV) therapy. A retrospective study was conducted in 109 human immunodeficiency virus (HIV)-infected patients who were infected with HCV genotypes 1 or 4 who had received pegylated interferon (pegIFN)-ribavirin.
View Article and Find Full Text PDFObjectives: To study the correlation between the HLA-B*5701 allele and the single nucleotide polymorphism in HCP5 (rs2395029).
Patients And Methods: All HIV patients naive for abacavir seen at our institution between September 2007 and December 2008 were prospectively screened for HLA-B*5701. HCP5 rs2395029 genotyping was carried out by allelic discrimination using the TaqMan 5'-nuclease assay.
Background: Tenofovir is one of the most widely used antiretroviral drugs. Tenofovir undergoes renal clearance by a combination of glomerular filtration and active tubular secretion. Although rare, the mechanism by which tenofovir causes renal damage is not well characterized.
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