Multiple systemic diseases complicated by bisphosphonate osteonecrosis: a case report.

Aims: this work aims at demonstrating that multiple systemic conditions, in association with the development of bisphosphonate associated osteonecrosis of the jaw (ONJ), increase the risk of complications and may lead to hospitalization. For this reason the dental approach to patients with multisystem disease should be carefully managed by a team of specialists.

Case Report: a case of mandibular necrosis associated with intake of oral bisphosphonates in a complex systemic context is described.

Implant rehabilitation in patients irradiated for head and neck cancer: role of Intensity-Moduled Radiotherapy (IMRT) in planning the insertion site.

Purpose: currently, head and neck irradiation is not considered an absolute contraindication for implant placement (1), especially due to the transition from conventional to conformal radiotherapy. However, there is a difference in the success rate of implant placement between irradiated and non-irradiated bones (5). Successful osseointegration is mainly affected by the total dose of radiation (6).

Surgical protocol in patients at risk for bisphosphonate osteonecrosis of the jaws: clinical use of serum telopetide CTX in preventive monitoring of surgical risk.

Aim: This study investigates the association between cross linked C-terminal telopetide test (CTX) and individual surgical risk of osteonecrosis in patients taking oral bisphosphonates.

Materials And Methods: 32 patients receiving bisphosphonate were treated surgically. Patients were divided into three groups according to type of drug administrated and were subjected to a treatment of oral surgery, such as simple tooth extractions and extraction of all residual teeth of the oral cavity, upon evaluation of CTX values and antibiotic prophylaxis.