Publications by authors named "Loren Moon"
Article Synopsis
- The study investigates pathogenic microorganisms present in the corneal epithelial layer of patients with keratoconus, comparing samples from ten keratoconus eyes and three healthy controls.
- DNA was extracted and analyzed using metagenomic next-generation sequencing (mNGS), which showed low microbial counts in both groups, with no significant differences between them.
- The predominant microbial group found was Proteobacteria, and the results suggest that a chronic infection is unlikely to contribute to the development of keratoconus, though an acute infection may still play a role in its onset.
Purpose: The objective of this study is to perform a histological analysis of Bowman layer (BL) grafts.
Methods: BL grafts were procured from 13 human cadaver corneal tissues using 3 different donor preparation techniques. Subsequently, the grafts were fixed in 10% buffered formalin phosphate and embedded in paraffin.
Purpose: Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII (), which localises to Bowman's layer (BL), is thought to function in stress-bearing areas, such as BL. Given the putative protective role of in biomechanical stability, this study aims to characterise expression in all corneal layers involved in KC.
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