Publications by authors named "Lorea Chaparro-Gonzalez"
When new antitumor therapy drugs are discovered, it is essential to address new target molecules from the point of view of chemical structure and to carry out efficient and systematic evaluation. In the case of natural products and derived compounds, it is of special importance to investigate chemomodulation to further explore antitumoral pharmacological activities. In this work, the compound podophyllic aldehyde, a cyclolignan derived from the chemomodulation of the natural product podophyllotoxin, has been evaluated for its viability, influence on the cell cycle, and effects on intracellular signaling.
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- - A significant number of patients with myelodysplastic syndromes (MDS) do not respond to treatment with hypomethylating agents (HMAs), but the reasons for this resistance are mostly unclear.
- - This study investigates the epigenomic profiles of MDS patients treated with azacitidine to uncover insights into the lack of response to HMAs.
- - The findings aim to enhance understanding of the DNA methylation changes in MDS, which could help predict treatment outcomes and improve therapies.