[Association of the ABO blood group system and hip joint dysplasia].

On the basis of distribution of ABO blood groups among 963 sick children with dysplastic pathology of hip joint and 1402 Georgians from among the total population of the city of Tbilisi there have been obtained significant associations of 0 group with this pathology. The hypothesis about genetic community of these symptoms has been rejected. Phenotypic correlations have demonstrated that 0 group of blood promotes an expression of hereditary predisposition to the hip joint dysplastic pathology.

[Genetic and environmental factors in the families of children with dystrophic bone cysts].

On the basis of data of 49 probands' families with dystrophic osseous, cyst, 12 probands' families with giant cell tumor and 55 children from the general population by means of clinical and multidimensional-genetical analysis (cluster, discriminant) have been revealed genetical and environmental factors, contributing to the formation of the osseous cysts in children. There have been developed the directions of the search of the "principal" environmental and genetical factors, determined the qualitative criteria of the factor significance, revealed the structures of the mutual connection of the significant factors and obtained their prognostication value definition.

[The correlations of dysplastic hip joint pathology with fetal breech presentation].

In the article are discussed the causes of hip joint instability at breech presentation. In the article are presented the results of examination of 116 probands with hip joint dysplasia, aged 5-15 years, and 69 breech presentation born probands, It has been carried out genetic-correlative analysis on the basis of population frequency and frequency among the probands' relatives, differentiated in accordance with the signs discussed. The principal cause of the hip joint dysplastic pathology formation at breech presentation is the mechanical factor.

[Structure of the correlations of genetic and environmental factors in congenital hip dislocation].

The aim of this paper was to determine the mechanisms of development or manifestations of the congenital dislocation of the hip by the method of multivariate analysis. The source of information were the family data about 300 children with congenital dislocation of the hip aged from 3 months to 15 years who had not been specially selected from those treated at the Centre and 300 children of the same age from unselected population. All the examinees were Georgians by nationality.

[Hereditary hypermobility of the joints].

The authors applied clinico-genetic methods of analysis to work out the data concerning familial spread of hypermobility of the joints (567 inhabitants of Tbilisi, 302 children with congenital dislocation of the hip joint). A common genetic character of this pathology and congenital dislocation of the hip was established (88% of common genes). Approximate evaluations of relative contribution of the genetic component into the general dispersion (93%) and of the penetrance of the gene were obtained.

[Genetic similarity of various orthopedic anomalies].

Genetic-mathematical analyses have proved that some orthopaedic anomalies are interconnected, have genetic communion, one of its components being the general dysplasia of connective tissue.