Publications by authors named "Lopez-Gutierrez Tomas"
Interaction of Some Amino-Nitrile Derivatives with Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Using a Theoretical Model.
Drug Res (Stuttg)
July 2023
Background: Some studies indicate that the angiogenesis process is related to vascular endothelial growth factor, which can interact with endothelial cell surface receptors (VEGF-R1, VEGF-R2, and VEGF-R3); this biochemical process and other factors result in the promotion and growth of new blood vessels under normal conditions. However, some studies indicate that this phenomenon could also occur in cancer cells. It is important to mention that some amino derivatives have been prepared as VEGF-R1 inhibitors; however, their interaction with VEGF-R1 is not clear, perhaps due to different experimental approaches or differences in their chemical structure.
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- The study investigates the antifungal and biosurfactant properties of lipopeptides produced by the marine bacterium subsp. MC6B-22, reporting a peak yield of 556 mg/mL at 84 hours.
- It identifies mycosubtilin as the main lipopeptide, confirmed through multiple purification and identification methods, and uncovers a broad-spectrum antifungal activity against ten tropical crop pathogens.
- The lipopeptide maintains stable biosurfactant and bioemulsifying activities across various salinity and pH levels, highlighting the MC6B-22 strain's potential for agricultural biocontrol and bioremediation applications.
Background: There are studies, which suggest that some diazocine derivatives can exert effects on the cardiovascular system; however, these effects are not very clear.
Objective: The aim of this research was to evaluate the biological activity of a diazocine derivative against heart failure translated as area infarct.
Methods: Biological activity produced by diazocine derivatives against heart failure was determinate using an ischemia/reperfusion injury model.
Background: Several drugs with inotropic activity have been synthesized; however, there is very little information on biological activity exerted by steroid derivatives in the cardiovascular system.
Objective: The aim of this research was to prepare a steroid-pyridine derivative to evaluate the effect it exerts on left ventricular pressure and characterize its molecular interaction.
Methods: The first stage was carried out through the synthesis of a steroid-pyridine derivative using some chemical strategies.
Article Synopsis
- * Compounds 4 and 5 were highlighted for their significant ability to reduce heart failure symptoms, specifically by decreasing the infarct area compared to other tested compounds.
- * Both compounds lowered left ventricular pressure in a dose-dependent way, and this effect was significantly blocked by the presence of methoctramine, indicating their action involves M-muscarinic receptor activation.