Typical endocrine disrupting chemicals in newborns with congenital hypothyroidism: Concentrations, exposure assessment, and potential risks.

Congenital hypothyroidism (CH) has been reported as a prevalent endocrine disorder in newborns. Endocrine disrupting chemicals (EDCs) have been widely detected in humans and can influence endocrine function, especially thyroid function, and neonates as a susceptible population may be more prone to suffer from CH through exposure to various EDCs. In this study, the concentrations and composition profiles of several typical EDCs were determined in 266 serum samples collected from newborns with (n = 136) and without CH (n = 130) in Beijing, China from 2018 to 2020.

A novel technique for the single-port laparoscopic percutaneous extraperitoneal closure (SLPEC) of paediatric isolated giant inguinal hernias using double-modified hernia needles.

The objective was to explore the efficacy of single-port laparoscopic percutaneous extraperitoneal closure using double-modified hernia needles with hydrodissection (SLPEC group) and two-port laparoscopic percutaneous extraperitoneal closure (TLPEC group) for the treatment of giant indirect inguinal hernias in children. We performed a retrospective review of all children with giant indirect inguinal hernias (inner ring orifice diameter ≥ 1.5 cm) who underwent laparoscopic high ligation of the hernia sac at FuJian Children's Hospital from January 2019 to December 2021.

Evaluating testicular function changes in unilateral cryptorchid chinese infants underwent orchidopexy in the first year of life.

Objective: Management of cryptorchidism is typically recommended within the first 18 months of life to maximize fertility potential. However, there is a paucity of longitudinal postoperative data for Chinese infants. We aim to evaluate the Testicular function change when the procedure is done within the first year of life.

The effect of scrotal versus inguinal orchiopexy on the testicular function of children with clinically palpable, inguinal undescended testis: a randomized controlled trial.

To compare the impact of the scrotal vs inguinal orchidopexy approach on the testicular function of infants with cryptorchidism, a randomized controlled trial was conducted involving boys who were 6-12 months old at surgery and were diagnosed with clinically palpable, inguinal undescended testis. Between June 2021 and December 2021, these boys at Fujian Maternity and Child Health Hospital (Fuzhou, China) and Fujian Children's Hospital (Fuzhou, China) were enrolled. Block randomization with a 1:1 allocation ratio was employed.

Several typical endocrine-disrupting chemicals in human urine from general population in China: Regional and demographic-related differences in exposure risk.

Endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment, and human exposure to these pollutants has caused great public concern. Five groups of EDCs, including parabens, antimicrobials (triclosan (TCS) and triclocarban (TCC)), bisphenols (BPs), tetrabromobisphenol A and its alternatives (TBBPAs), and benzophenones, in urines of general populations from three cities with different economic levels in China were determined simultaneously to evaluate the coexposure levels of such chemicals. The total concentration of target compounds was approximately two times higher in the urines from Chengdu (a first-tier city; geometric mean: 2.

Occurrence, spatial distribution and ecological risk assessment of phthalate esters in water, soil and sediment from Yangtze River Delta, China.

A total of 96 water, soil, and sediment samples, collected from 32 sampling sites in the Yangtze River Delta (YRD) region, were analyzed for 9 phthalate esters (PAEs). The sum concentrations of 9 PAEs (∑PAEs) in the water, soil, and sediment samples were 2.23-6.

Tumor volume: a new prognostic factor of oncological outcome of localized clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is one of the most frequent malignancies; however, the present prognostic factors was deficient. This study aims to explore whether there is a relationship between tumor volume (TV) and oncological outcomes for localized ccRCC.

Methods: Seven hundred forty-nine localized ccRCC patients underwent surgery in our hospital.

Occurrence, fate, and risk assessment of typical tetracycline antibiotics in the aquatic environment: A review.

Tetracyclines (TCs), used as human and veterinary medicines, are the most widely used antibiotics. More than 75% of TCs are excreted in an active form and released into the environment through human and animal urine and feces, causing adverse effects on the ecological system and human health. Few articles review the environmental occurrence and behaviors of TCs, as well as their risks and toxicities.