Publications by authors named "Longtao He"

Article Synopsis
  • The study investigates the use of a targeted nanotherapeutic drug that responds to the tumor microenvironment, specifically focusing on its effects on PBK in medulloblastoma cells (Daoy and ONS-76).
  • Utilizing the rabies virus glycoprotein (RVG), the researchers developed a nanocomplex (HPAA/RVG/PBK-siRNA) that includes a microenvironment stimulus (glutathione) and delivers PBK-siRNA for targeted therapy.
  • Various analytical methods were used to evaluate the characteristics and effectiveness of this nanocomplex, demonstrating potential benefits for improving treatment strategies in medulloblastoma.
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Objectives: Mpox continues to spread in China, and stakeholders' experiences may help inform prevention and control strategies.

Study Design: Qualitative study.

Methods: A qualitative study across 14 Chinese cities recruited stakeholders from Centers for Disease Control and Prevention (CDCs), community-based organizations (CBOs), and hospitals involved in curbing mpox.

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The uptake of COVID-19 booster vaccination among older adults in China is suboptimal. Here, we report the results of a parallel-group cluster-randomized controlled trial evaluating the efficacy of promoting COVID-19 booster vaccination among grandparents (≥60 years) through a health education intervention delivered to their grandchildren (aged ≥16 years) in a Chinese cohort (Chinese Clinical Trial Registry: ChiCTR2200063240 ). The primary outcome was the uptake rate of COVID-19 booster dose among grandparents.

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Objective: Sexual health plays a vital role in healthy aging. However, little is known about the sexual attitudes of and the utilization of sexual and reproductive health services by older women in China. This article is based on a qualitative study of older Chinese women in suburban areas to examine their attitudes toward sexuality and their utilization of sexual and reproductive health services.

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Monkeypox (mpox), a viral zoonotic disease, is spreading worldwide. However, evidence that informs prevention and control strategies in the Asia Pacific Region is very limited. Our study aims to investigate the experiences of mpox patients from infection to treatment to provide scientific basis for the prevention and control.

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Delayed retirement initiative proposed in China attaches greater importance to the sustainability of pension systems and the labour shortage, but less to the health status of older people. The existing social health insurance and pension system are not well established to match this initiative. This study investigates the policy mix of delayed retirement, employment-based social health insurance, social pension participation for health status of older people.

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Medulloblastoma (MB) is a frequently occurring malignant brain tumor in children, and many of these tumors are identified by the abnormal activation of the Sonic Hedgehog (SHH) pathway. Although the Shh inhibitor GDC0449 initially shows some effectiveness in certain tumors, they eventually recur due to drug resistance mechanisms, highlighting the need for new treatment options. In this study, we explore whether GDC0449 induces autophagy in the human MB cell lines.

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Voluntary medical male circumcision (VMMC) may be incorporated into HIV prevention services for men who have sex with men (MSM). We conducted a mixed-methods study to elucidate barriers and facilitators to, and experience of, VMMC among MSM. Participants were MSM aged 18 years and older who were enrolled in an ongoing multicenter randomized controlled trial (RCT) to evaluate VMMC to prevent HIV among MSM in China.

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Article Synopsis
  • * Findings indicate that while social work scholars in China recognize the importance of research ethics, they often do not fully adhere to internationally accepted ethical principles, such as respect for persons.
  • * The research highlights the need for improved education on research ethics, addresses challenges posed by the digital age, and emphasizes the importance of considering Chinese cultural factors when developing ethical protocols for social work research in China.
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Qualitative meta-synthesis is a coherent approach to answering an overarching research question by synthesising past qualitative studies so as to create new meanings from their results. We conducted a qualitative meta-synthesis to systematically evaluate and integrate the caregiving experiences of adult children providing care for an elderly parent with cancer. The search was conducted in the databases Web of Science, PubMed, Embase, MEDLINE, Cochrane Library, Grew Literature in the Health Sciences, CNKI, WanFang Data, VIP, SINOMED and China Academic Journals as well as Chinese grey literature databases (China Academic Conference Literature Database/, National Science and Technology Library) from inception to June 9, 2021.

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Article Synopsis
  • A three-stage strength-based meaning intervention (SMI) was tested to improve mental health in individuals with physical disabilities from low-income communities through a randomized controlled trial involving 50 participants.
  • Post-intervention results showed significant improvements in strength knowledge, strength use, and sense of meaning in life for the intervention group, which were maintained three months later, although mental health improvements showed no significant changes at follow-up.
  • The study suggests that the SMI model could be an effective method for enhancing mental well-being by focusing on individual strengths and purpose in life.
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Article Synopsis
  • The COVID-19 pandemic has significantly impacted health systems in low- and middle-income countries (LMICs), prompting the International Society of Global Health (ISoGH) to identify key research priorities to mitigate its effects.
  • Using the CHNRI method, they engaged 79 experts who proposed 192 research questions, which were later scored by 52 experts based on criteria like feasibility and potential impact.
  • The top research priorities included addressing barriers to COVID-19 vaccination access, understanding vaccine hesitancy, effective healthcare strategies for managing the pandemic, and assessing the needs of vulnerable populations in LMICs.
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This study intends to reveal the underlying structural inequity in vulnerability to infection of the novel coronavirus disease pandemic among children and youth. Using multi-source data from New York Times novel coronavirus disease tracking project and County Health Rankings & Roadmap Program, this study shows that children and youth in socioeconomically disadvantaged status are faced with disproportionate risk of infection in this pandemic. On the county level, socioeconomic disadvantages (i.

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This article reports on research that explored rural migrant workers' experiences of returning to their hometown to provide care for elderly parents diagnosed with cancer. The authors used a culturally integrated approach to Foucauldian discourse analysis to consider how 24 participants narrated their experiences of care in China. The discourse of care demonstrated a strong commitment to filial piety despite their unique care challenges, and this commitment was bolstered by discourses that emphasized how much parents had sacrificed, as well as by a persistent forgetting of experiences or background details that suggested any lack of parental sacrifice in recent Chinese history.

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This systematic review of published quantitative research was conducted to explore the effects of spirituality-integrated interventions for informal caregivers of terminally ill patients. Multiple databases were searched for articles published between January 2004 and November 2019. Twelve randomized controlled trials were identified.

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Introduction: Studies on various types of digital-technology-based psychotherapies (DTPs) have indicated that they are effective for post-traumatic stress disorder (PTSD) symptom relief among adults. The intervention efficacy or effectiveness hierarchy, however, is still not clear. Therefore, we propose to conduct a network meta-analysis to assess the relative effectiveness of various types of DTPs.

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Filial piety is a highly relevant cultural mechanism that mediates the impacts of caregiving experiences on Chinese adult children, worldwide but perhaps especially in rural China. We undertook qualitative research with 24 migrant workers who were caring for an elderly parent diagnosed with terminal cancer. Research aims included building a comprehensive explanatory theoretical model for filial piety's mediating role in caregivers' lived experiences.

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The current dominant approach to active ageing policy in the EU and the UK is the productivist approach. Drawing on Weber's concepts of instrumental rationality and value rationality, this article argues that this approach is principally informed by instrumental rationality and thus has the potential to instrumentalize older persons, to become an oppressive ideological narrative, and to ignore the unique developmental meanings in late life. To avoid these pitfalls, the article proposes balancing instrumental rationality with value rationality.

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Background: Many scholars claim that recent changes to Chinese society since economic reform have challenged longstanding forms of informal social care, such as filial piety. For instance there is a societal tension at work in contemporary Chinese society today. On the one hand decreasing co-residence in multi-generational households caused by rural-urban migration, population ageing, the fall in fertility and 'One-Child Policy', and women's increasing participation in the labour market, emphasises an individualised, wage earning centred society.

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