Publications by authors named "Longson Tsz Hin Pang"
Article Synopsis
- Urease is a nickel enzyme crucial for bacteria colonizing the human stomach, but delivering toxic nickel ions safely to its active site is a challenge.
- Cells utilize metallochaperones, proteins that transport these ions specifically to protein complexes, to solve this problem.
- The study detailed the structures of UreFD/urease and UreD/urease complexes using cryo-electron microscopy, revealing a tunnel mechanism that facilitates nickel ion delivery to urease’s active site.
