The problems of multidrug-resistant bacteria and environmental pollution associated with the abuse of antibiotics call for effective antibiotic alternatives. Here, gold@silvergold alloy nanoflowers (Au@AgAu ANFs) with distinct atomic structures are first fabricated and then demonstrated for in vivo inhibition of bacteria. The Au@AgAu ANFs display high antibacterial activity against the model Gram-negative bacterium Escherichia coli, with a minimum inhibitory concentration value of 4.
View Article and Find Full Text PDFIn this study, we described a novel method for highly sensitive and specific detection of chloramphenicol (CAP) based on engineered "hot" Au core-Ag shell nanostructures (Au@Ag NSs). Cy5-labeled DNA aptamer was embedded between the Au and Ag layers as a signal generator and target-recognition element, to fabricate uniform Au@Ag NSs with unexpected strong and stable SERS signals. The presented CAP can specifically bind to the DNA aptamer by forming an aptamer-CAP conjugate, and cause greatly decreased SERS signals of Au@Ag NSs.
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