Fabrication of self-healing hydrogel from quaternized N-[3(dimethylamino)propyl]methacrylamide copolymer for antimicrobial and drug release applications.

Self-healing hydrogels have attracted great attention in recent years because of their wide application in bioscience and biotechnology. In this study, P(DMAPMA-stat-DAA) were synthesized by Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization and quaternized to import antimicrobial properties. Then quaternized P(DMAPMA-stat-DAA) was used to prepare hydrogel containing acylhydrazone groups with Polyethylene oxide (PEO) diacylhydrazide as a cross-linking agent.

Exosomes derived from adipose tissue, bone marrow, and umbilical cord blood for cardioprotection after myocardial infarction.

Human mesenchymal stem cells (MSCs) have the potential for improving cardiac function following myocardial infarction (MI). This study was performed to explore the cardioprotection of bone marrow mesenchymal stem cells (BMMSCs), adipose tissue-derived mesenchymal stem cells (ADMSCs), and umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) for myocardium in rats after MI. MI models were established in rats, which were injected with PBS, BMMSCs, ADMSCs, and UCMSCs.

Linc01230, transcriptionally regulated by PPARγ, is identified as a novel modifier in endothelial function.

Evidence is growing that PPARγ could improve the bioavailability of NO in pathological conditions to maintain endothelial function by activating Akt/eNOS pathway. LincRNAs participate in regulating development of cardiovascular diseases. Although investigations have been made to delineate the function of PPARγ and lincRNAs, little is known about the regulation relationship between them, especially in endothelial cells.

[Heavy metals distribution characteristics and ecological risk evaluation in surface sediments of dammed Jinshan lake].

In order to reveal the pollution loading of heavy metals in Dammed Jinshan lake, six heavy metals (As, Cu, Pb, Cd, Zn, Cr) from 18 sediment samples were analyzed using ICP, and the distribution characteristics of heavy metals in the sediment were comprehensively evaluated through concentration coefficient, geo-acumulation indexes, potential ecological risk evaluation and traceability analysis. The results showed that (1) the average contents of As, Pb, Cu, Zn, Cr, Cd were 23.22, 26.