Curcumin is an efficacious therapeutic agent against Chilodonella uncinata via interaction with tubulin alpha chain as protein target.

Chilodonella, a parasitic ciliate that infects both cold water and warm water fish, can impede the growth of juvenile fish and cause considerable economic losses globally to freshwater aquaculture. In this study, the parasite was collected from both the gills and zygotes of largemouth bass (Micropterus salmoides). Isolated from diseased fish, the parasites were identified as Chilodonella uncinata based on morphological features and genetical diagnostic characterization using the partial small subunit ribosomal RNA gene.

Corrigendum: infection reshapes the intestinal microbiome and metabolome of big-belly seahorses: mechanistic insights of synergistic actions of virulence factors.

[This corrects the article DOI: 10.3389/fimmu.2023.

infection reshapes the intestinal microbiome and metabolome of big-belly seahorses: mechanistic insights of synergistic actions of virulence factors.

Uncovering the mechanism underlying the pathogenesis of induced enteritis is essential for global aquaculture. In the present study, we identified as a lethal pathogen of the big-belly seahorse () and revealed its pathogenic pattern and characteristics by updating our established bacterial enteritis model and evaluation system. Conjoint analysis of metagenomic and metabolomic data showed that 15 core virulence factors could mutually coordinate the remodeling of intestinal microorganisms and host metabolism and induce enteritis in the big-belly seahorse.

Flame evolution in shock-accelerated flow under different reactive gas mixture gradients.

The interaction between a planar shock wave and a spherical flame is studied numerically for an ethylene-oxygen-nitrogen gas mixture. Influences of different initial reactive gas mixture gradients on the shock-flame interaction are investigated by using high-resolution computational simulations. The results show that the different reactive gas mixture gradients can greatly affect the flame evolution in shock accelerated flow.