Ultraminiature and Flexible Sensor Based on Interior Corner Flow for Direct Pressure Sensing in Biofluids.

Conventional pressure sensing devices are well developed for either indirect evaluation or internal measuring of fluid pressure over millimeter scale. Whereas, specialized pressure sensors that can directly work in various liquid environments at micrometer scale remain challenging and rarely explored, but are of great importance in many biomedical applications. Here, pressure sensor technology that utilizes capillary action to self-assemble the pressure-sensitive element is introduced.

A novel microstructure inspired from and lizard skin and its enhanced uni-directional liquid spreading property.

With the discovery of the liquid spreading mechanism on the peristome of , many studies focusing on uni-directional liquid spreading microstructures have been carried out with an emphasis on structural improvement and the spreading mechanism. Although there are various kinds of microstructures that can accomplish small-scale liquid uni-directional transportation, liquid spreading has not been optimized on a slope because of the unwanted backward flow generated by fabrication defects; inspired by the microstructure of the peristome surface of and the topography of the lizard skin, in this study, we present an innovative, easily processed microstructure that possesses the property of intensified uni-directional liquid spreading even on an oblique substrate. This property is derived from a new, hybrid mechanism that can significantly enhance the uni-directional liquid transportation.

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface.

With the rapid development of Micro-electro-mechanical Systems (MEMS) fabrication technologies, many microelectrodes with various structures and functions have been designed and fabricated for applications in biomedical research, diagnosis and treatment through electrical stimulation and electrophysiological signal recording. The flexible MEMS microelectrodes exhibit excellent characteristics in many aspects beyond stiff microelectrodes based on silicon or metal, including: lighter weight, smaller volume, better conforming to neural tissue and lower fabrication cost. In this paper, we reviewed the key technologies in flexible MEMS microelectrodes for neural interface in recent years, including: design and fabrication technology, flexible MEMS microelectrodes with fluidic channels and electrode⁻tissue interface modification technology for performance improvement.

Enhanced Flexible Tubular Microelectrode with Conducting Polymer for Multi-Functional Implantable Tissue-Machine Interface.

Implantable biomedical microdevices enable the restoration of body function and improvement of health condition. As the interface between artificial machines and natural tissue, various kinds of microelectrodes with high density and tiny size were developed to undertake precise and complex medical tasks through electrical stimulation and electrophysiological recording. However, if only the electrical interaction existed between electrodes and muscle or nerve tissue without nutrition factor delivery, it would eventually lead to a significant symptom of denervation-induced skeletal muscle atrophy.