Publications by authors named "Longjie Ding"
Bioorg Chem
December 2024
Article Synopsis
- Non-small cell lung cancer (NSCLC) is a common type of lung cancer, and while the compound Gboxin has some anti-tumor properties, it doesn't work effectively against NSCLC in living organisms.
- Through optimization, researchers developed a new compound, Y9, which shows much stronger effects against NSCLC, inhibiting cell growth and inducing stress in cancer cells.
- Y9 also causes lysosomal dysfunction and hyperactive autophagy, leading to cancer cell death, and has demonstrated success in reducing tumor growth in animal models, making it a promising candidate for further development as an NSCLC treatment.
