Time-Sensitive Antibiotic Adjustments in Gram-Negative Bacteremia: A Survival Perspective.

BACKGROUND This retrospective study was designed to assess risk factors for increased 30-day mortality from bacteremia caused by Escherichia coli or Klebsiella pneumoniae and to calculate the optimal point of time for patients to move from inappropriate empirical antimicrobial therapy to appropriate treatment. MATERIAL AND METHODS This retrospective study analyzed data from 610 patients with a diagnosis of E. coli- and K.

Modulation of virulence and metabolic profiles in under indole-mediated stress response.

Indole, a crucial bacterial signaling molecule, plays a fundamental role in regulating various physiological processes within bacteria, including growth, acid tolerance, biofilm development, motility, and other cellular functions. Its regulatory influence extends beyond indole-producing bacteria, significantly impacting the physiological activities in non-indole-producing species. In this study, we demonstrate that indole enhances the pathogenicity and viability of using the infection model and serum killing assay.

The detection and utilization of volatile metabolomics in Klebsiella pneumoniae by gas chromatography-ion mobility spectrometry.

This research aimed to analyze the volatile compounds emitted during the proliferation of Klebsiella pneumoniae (K. pneumoniae) in the laboratory setting using gas chromatography-ion mobility spectrometry (GC-IMS) and to investigate the potential of volatile metabolomics for detecting carbapenemase-producing strains of K. pneumoniae.

Clinical features and antifungal treatment of invasive Scedosporium boydii infection: report of a case and literature overview.

Objective: This study aims to present a case of persistent mycetoma caused by Scedosporium boydii and undertake a systematic literature overview to elucidate the clinical characteristics and antifungal treatment exhibited by such patients.

Methods: We report the case of a 24-year-old female who sustained a Scedosporium boydii infection in her right foot over a decade ago following a nail puncture. Concurrently, a comprehensive literature overview was conducted on PubMed, focusing on documented cases of Scedosporium boydii infections with the intent of extracting relevant clinical data.

Analysis and application of volatile metabolic profiles of : a preliminary GC-IMS-based study.

Nosocomial infections caused by () may pose serious risks to patients, and early identification of pathogenic bacteria and drug sensitivity results can improve patient prognosis. In this study, we clarified the composition and relative content of volatile organic compounds (VOCs) generated by in tryptic soy broth (TSB) using gas chromatography-ion mobility spectrometry (GC-IMS). We explored whether imipenem (IPM) could be utilized to differentiate between carbapenem-sensitive (CSEC) and carbapenem-resistant (CREC).

Gas Chromatography-Ion Mobility Spectrometry Reveals Acetoin as a Biomarker for Carbapenemase-Producing Klebsiella pneumoniae.

BACKGROUND This study aimed to detect the volatile organic compound (VOC), 3-hydroxy-2-butanone (acetoin) using gas chromatography-ion mobility spectrometry (GC-IMS) in antimicrobial-resistant Klebsiella pneumoniae (K. pneumoniae) carbapenemase (KPC)-producing bacteria. MATERIAL AND METHODS Using stromal fluid of blood culture bottles (BacT/ALERT® SA) as the medium, 3-hydroxy-2-butanone (acetoin) released by K.

Gynecologic infection rates after ablation treatment for cervical intraepithelial neoplasia grade 2 and higher (CIN2+): Secondary analysis of a non-inferiority randomized trial.

Although concerns have been raised regarding potential infection and morbidity in women undergoing ablation treatment for cervical precancer in low- and middle-income countries (LMIC), there is extremely limited data to substantiate this claim. This is a secondary analysis of a randomized non-inferiority trial (id: NCT03084081) that compares the efficacy and safety of three ablation treatments for biopsy-confirmed cervical intraepithelial neoplasia grade 2 or higher (CIN2+): CO2 gas-based cryotherapy, non-gas cryotherapy, and thermal ablation (TA). Here, we present findings regarding the incidence of sexually transmitted infections (STI) and vaginitis post-treatment.

Clinical Characteristics, Prognosis and Treatment of Bloodstream Infections with Complex in a Chinese Tertiary Hospital: A Retrospective Study.

Objective: This research aimed to analyze the clinical characteristics, prognosis, and antimicrobial treatment of bloodstream infections (BSI) caused by complex (ECC).

Methods: The clinical data of patients with bloodstream infections caused by complex from April 2017 to June 2023 were collected retrospectively. These data were then analyzed in subgroups based on the detection results of extended-spectrum β-lactamase (ESBL), 30-day mortality, and the type of antimicrobial agent used (β-lactam/β-lactamase inhibitor combinations (BLICs) or carbapenems).

Risk Factors for 30-Day Mortality in Patients with Bacteremic Pneumonia Caused by and : A Retrospective Study.

Objective: and are prevalent Gram-negative microorganisms responsible for pneumonia, as well as the primary pathogens causing bacteremic pneumonia. The objective of this research is to analyze the risk factors associated with bacteremic pneumonia caused by these pathogens and develop a predictive model.

Patients And Methods: This retrospective investigation encompassed a cohort of 252 patients diagnosed with or -induced bacteremic pneumonia between 2018 and 2022.

Biological characteristics and pathogenicity of a Staphylococcus aureus strain with an incomplete hemolytic phenotype isolated from bovine milk.

Staphylococcus aureus is a common pathogen capable of infecting both humans and animals and causing various severe diseases. Here, we aimed to determine the biological features and pathogenicity of S. aureus strain Sa9, of the incomplete hemolysis phenotype, isolated from bovine milk.

Clinical Characteristics and Prognosis of Hospital-Acquired Bacteremic Pneumonia versus Bacteremic Pneumonia: A Retrospective Comparative Study.

Objective: This research aimed to investigate the variations in clinical features and prognosis of HABP caused by and . We also aimed to evaluate the risk variables related to 30-day death in the investigated groups.

Methods: A single-center retrospective cohort research lasting four years was performed.

Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study.

BACKGROUND Lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios have been implicated in predicting mortality in sepsis patients. However, their prognostic value and relationship to sepsis severity require further investigation. This retrospective study aimed to assess the prognostic value of lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios in septic patients admitted to the Intensive Care Unit (ICU).

Rapid Identification of Carbapenemase-Producing Using Headspace Solid-Phase Microextraction Combined with Gas Chromatography-Mass Spectrometry.

Background: Carbapenemase-producing is an unprecedented threat to public health, and its detection remains challenging. Analysis of microbial volatile organic compounds (VOCs) may offer a rapid way to determine bacterial antibiotic susceptibility.

Purpose: The aim of this study was to explore the VOCs released by carbapenemase-producing carbapenem-resistant (CRKP) using headspace solid-phase microextraction/gas chromatography-mass spectrometry (HS-SPME/GC-MS).

Methicillin-resistant in China: a multicentre longitudinal study and whole-genome sequencing.

The aim of this study was to investigate the genomic epidemiology of MRSA in China to identify predominant lineages and their associated genomic and phenotypic characteristics. In this study, we conducted whole-genome sequencing on 565 MRSA isolates from 7 provinces and municipalities of China between 2014 and 2020. MRSA isolates were subjected to MLST, typing, SCC typing, analysis of virulence determinants and antimicrobial susceptibility testing.

Identification of methicillin-resistant ST8 isolates in China with potential high virulence.

Methicillin-resistant (MRSA) ST8 strains have spread worldwide, causing outbreaks in various regions. However, this clone has only been sporadically reported in China. Consequently, detailed information regarding the phylogeny and potential virulence of ST8 strains in China remains unknown.

Corrigendum: First Report of Coexistence of and β-Lactamase Genes as Well as Colistin Resistance Gene in a Transferrable Plasmid of a Clinical Isolate of .

[This corrects the article DOI: 10.3389/fmicb.2021.