Publications by authors named "Longhai Tian"
Article Synopsis
- - The study examined how the N-methyladenosine (m6A) modification affects long noncoding RNA (lncRNA) regulation and contributes to atherosclerosis progression through experiments on human aortic endothelial cells and a mouse model.
- - Researchers found that knocking down the m6A writer protein METTL3 reduced pyroptosis in the endothelial cells, while the lncRNA H19 was identified as a key target of METTL3's modification effects.
- - Elevated levels of m6A and increased expression of METTL3 and METTL14 were observed in both the atherosclerotic mouse aortas and oxidized LDL-treated human cells, indicating that METTL3 enhances atherosclerosis by influencing
H19 lncRNA triggers ferroptosis, exacerbating ox-LDL-induced artery endothelial cell damage in vitro.
Clin Hemorheol Microcirc
October 2024
Background: The precise association between lncRNA H19 and ferroptosis in the context of atherosclerosis remains uncertain.
Objective: This study is to clarify the underlying process and propose novel approaches for the advancement of therapeutic interventions targeting atherosclerosis.
Methods: Assessment of ferroptosis, which entails the evaluation of cell viability using CCK-8 and the quantification of intracellular MDA, GSH, and ferrous ions.
Background And Aims: Electrophysiological characteristics and radiofrequency catheter ablation (RFCA) of premature ventricular contractions (PVCs) originating from the superior septal left ventricle (SSLV) have not yet been fully characterized.
Methods And Results: This study included 247 patients who underwent RFCA for PVCs arising from the ventricular outflow tract between February 2020 and August 2022. The successful ablation site was on the SSLV in 37 of the 247 patients.
Article Synopsis
- Radiofrequency catheter ablation is recognized as the primary treatment option for idiopathic premature ventricular complexes (PVCs) and ventricular tachycardias (VTs), but its effectiveness varies by type of PVC/VT.
- A retrospective study conducted in a high-volume center in Guizhou, China, analyzed 1028 patients who underwent their first catheter ablation between 2013 and 2022, assessing factors like success rates and complications.
- The study revealed a 90.3% acute success rate, with complications more prevalent in left ventricular PVC/VT patients, while follow-up showed certain types of PVC/VTs had lower recurrence risk, indicating catheter ablation is effective for various locations except for those presenting with left
Article Synopsis
- Cardiac CT (CCT) is being evaluated for its effectiveness in detecting left atrial appendage (LAA) thrombus in patients with atrial fibrillation, using trans-oesophageal echocardiography (TEE) as the benchmark.
- The study involved 726 patients from a Chinese hospital and found that CCT was able to detect 89.3% of LAA thrombi but only 48.3% of thrombi located at the LAA ostium, revealing discrepancies in detection rates.
- The analysis concluded that CCT is generally less sensitive than TEE for identifying LAA thrombi, particularly for smaller ones with fast blood flow, suggesting that TEE remains the more reliable method for this specific
Introduction: This study aimed to identify the characteristics of unipolar and bipolar electrogram (UniEGM and BiEGM) in guiding successful ablation of premature ventricular contractions (PVCs) originating from the free wall of the ventricular aspect of the tricuspid annulus (TA). We hypothesized that the negative concordance pattern (NCP) on the onset of UniEGM and BiEGM, together with the least value of the difference between the earliest BiEGM and UniEGM dV/dTmax, might improve the accuracy of conventional mapping.
Methods And Results: Thirty consecutive patients who underwent successful catheter ablation from February 2018 to July 2021 were retrospectively analyzed.
As the rate of percutaneous coronary intervention increases, in-stent restenosis (ISR) has become a burden. Random forest (RF) could be superior to logistic regression (LR) for predicting ISR due to its robustness. We developed an RF model and compared its performance with the LR one for predicting ISR.
View Article and Find Full Text PDFBackground: Percutaneous coronary intervention (PCI) of heavily calcified lesions (HCLs) is associated with higher complication rates and worse clinical outcomes. Cutting balloon (CB) has been widely used for HCLs, but patients' prognosis had not been fully clarified. The study aimed to compare 3-year clinical outcomes between patients with HCLs that are treated with CBs and those with non-HCLs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the origin distribution of right ventricular outflow tract (RVOT) ventricular arrhythmias (VAs) and compares the effectiveness of two ablation techniques: the reversed U-curve (supravalvular) method and the antegrade (subvalvular) method.
- Out of 61 patients with idiopathic RVOT-type VAs, 55.7% had early activation sites located above the pulmonary valves; the initial ablation success rate was higher in the supravalvular method (75.8%) compared to the subvalvular method (57.1%).
- Both ablation strategies were found to be effective together, particularly for ipsilateral early activation sites, indicating that a dual approach
Background: The complexity of left atrial appendage (LAA) in patients with nonvalvular atrial fibrillation (NVAF) is closely related to LAA thrombosis and stroke incidence. But the classification of LAA morphology is not uniform and controversial.
Hypothesis: This study divided the LAA into two categories according to the LAA morphology to investigate the risk of thrombosis related to the LAA structural complexity in NVAF patients.