MiR-497-5p Ameliorates Deep Venous Thrombosis by Facilitating Endothelial Progenitor Cell Migration and Angiogenesis by Regulating LITAF.

Deep vein thrombosis (DVT) is a clinical manifestation of venous thromboembolism and a major global burden of cardiovascular disease. In recent years, the crucial role of microRNAs (miRNAs) in cardiovascular disease has been confirmed. Here, we aimed to investigate the specific effect of miR-497-5p on DVT.

LncRNA HCG18 affects aortic dissection through the miR-103a-3p/HMGA2 axis by modulating proliferation and apoptosis of vascular smoothing muscle cells.

Background: Aortic Dissection (AD) is a vascular disease with a high mortality rate and limited treatment strategies. The current research analyzed the function and regulatory mechanism of lncRNA HCG18 in AD.

Methods: HCG18, miR-103a-3p, and HMGA2 levels in the aortic tissue of AD patients were examined by RT-qPCR.

Physalin A Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Inhibition of PI3K/Akt Signaling Pathway.

Physalin A (PA) is a bioactive withanolide with multiple pharmacological properties and has been indicated to be cytotoxic to hepatocellular carcinoma (HCC) cell line HepG2. This study aims to explore the mechanisms underlying PA antitumor activity in HCC. HepG2 cells were exposed to various concentrations of PA.

Design, Fabrication, and Mechanical Properties of T-700 Multiaxial-Warp-Knitting-Needled-C/SiC Composite and Pin.

In this paper, the 12k T-700 Multiaxial-Warp-Knitting-Needle (MWK-N) C/SiC composite and pin were designed and fabricated using the isothermal chemical vapor infiltration (ICVI) method. The composite's microstructure and mechanical properties were examined by subjection to tensile and interlaminar shear tests. Three types of double-shear tests were conducted for C/SiC pins, including shear loading perpendicularly, along, and at 45° off-axial to the lamination.

Cyclic Thermal Shock Damage Behavior in CVI SiC/SiC High-Pressure Turbine Twin Guide Vanes.

In this paper, the SiC/SiC high-pressure turbine twin guide vanes were fabricated using the chemical vapor infiltration (CVI) method. Cyclic thermal shock tests at different target temperatures (i.e.

Damage Evolution and Fracture Behavior of C/SiC Minicomposites with Different Interphases under Uniaxial Tensile Load.

In this paper, the tensile damage and fracture behavior of carbon fiber reinforced silicon carbide (C/SiC) minicomposites with single- and multiple-layer interphases are investigated. The effect of the interphase on the tensile damage and fracture behavior of C/SiC minicomposites is analyzed. The evolution of matrix cracking under the tensile load of the C/SiC minicomposite with a notch is observed using the digital image correlation (DIC) method.

Monotonic and Cyclic Loading/Unloading Tensile Behavior of 3D Needle-Punched C/SiC Ceramic-Matrix Composites.

In this paper, monotonic and cyclic loading/unloading tensile behavior of four different 3D needle-punched C/SiC composites are investigated. Under tensile loading, multiple micro parameters of tensile tangent modulus, tensile strength, and fracture strain are used to characterize tensile damage and fracture behavior. Under cyclic loading/unloading, multiple damage micro parameters of unloading residual strain, tensile peak strain, hysteresis loops width, hysteresis loops area, unloading and reloading inverse tangent modulus (ITM) are used to describe the tensile damage evolution.

Modeling Tensile Damage and Fracture Behavior of Fiber-Reinforced Ceramic-Matrix Minicomposites.

Evolution of damage and fracture behavior of fiber-reinforced mini ceramic-matrix composites (mini-CMCs) under tensile load are related to internal multiple damage mechanisms, i.e., fragmentation of the brittle matrix, crack defection, and fibers fracture and pullout.

A Micromechanical Fatigue Limit Stress Model of Fiber-Reinforced Ceramic-Matrix Composites under Stochastic Overloading Stress.

Fatigue limit stress is a key design parameter for the structure fatigue design of composite materials. In this paper, a micromechanical fatigue limit stress model of fiber-reinforced ceramic-matrix composites (CMCs) subjected to stochastic overloading stress is developed. The fatigue limit stress of different carbon fiber-reinforced silicon carbide (C/SiC) composites (i.

Effect of Stochastic Loading on Tensile Damage and Fracture of Fiber-Reinforced Ceramic-Matrix Composites.

In this paper, the effect of stochastic loading on tensile damage and fracture of fiber-reinforced ceramic-matrix composites (CMCs) is investigated. A micromechanical constitutive model is developed considering multiple damage mechanisms under tensile loading. The relationship between stochastic stress, tangent modulus, interface debonding and fiber broken is established.

Modeling Temperature-Dependent Vibration Damping in C/SiC Fiber-Reinforced Ceramic-Matrix Composites.

In this paper, the temperature-dependent vibration damping in C/SiC fiber-reinforced ceramic-matrix composites (CMCs) with different fiber preforms under different vibration frequencies is investigated. A micromechanical temperature-dependent vibration damping model is developed to establish the relationship between composite damping, material properties, internal damage mechanisms, and temperature. The effects of fiber volume, matrix crack spacing, and interface properties on temperature-dependent composite vibration damping of CMCs and interface damage are analyzed.

Cyclic-Dependent Damage Evolution in Self-Healing Woven SiC/[Si-B-C] Ceramic-Matrix Composites at Elevated Temperatures.

Cycle-dependent damage evolution in self-healing, 2.5D woven Hi-Nicalon SiC/[Si-B-C] and 2D woven Hi-Nicalon SiC/[SiC-BC] ceramic-matrix composites (CMCs) at 600 and 1200 °C was investigated. The cycle-dependent damage parameters of internal friction, dissipated energy, Kachanov's damage parameter, and broken fiber fraction were obtained to describe damage development in self-healing CMCs.

Stress-Rupture of Fiber-Reinforced Ceramic-Matrix Composites with Stochastic Loading at Intermediate Temperatures. Part I: Theoretical Analysis.

Under stress-rupture loading, stochastic loading affects the internal damage evolution and lifetime of fiber-reinforced ceramic-matrix composites (CMCs) at intermediate temperatures. The damage mechanisms of the matrix cracking, fiber/matrix interface debonding and oxidation, and fiber fracture are considered in the analysis of stochastic loading. The strain, fiber/matrix interface debonding and oxidation length, and the broken fibers fraction versus the time curves of SiC/SiC composite under constant and three different stochastic loading conditions are analyzed.

Fouling-resistant membranes for separation of oil-in-water emulsions.

Separation by membrane technology of oily wastewater, especially emulsified oil/water mixtures, has become a topic of intensive study in recent years, and membrane fouling remains a challenge. In this work, porous polycarbonate membranes were coated with poly(diallyldimethylammonium chloride)/polystyrene sulfonate (PDDA/PSS) multilayers the facile layer-by-layer deposition technique to improve their fouling resistance for separation of oil-in-water emulsions stabilized by ionic surfactants. The permeation flux for the virgin membrane was found to decrease by ∼90% in 10 cycles due to fouling.

Comparisons of Damage Evolution between 2D C/SiC and SiC/SiC Ceramic-Matrix Composites under Tension-Tension Cyclic Fatigue Loading at Room and Elevated Temperatures.

In this paper, comparisons of damage evolution between 2D C/SiC and SiC/SiC ceramic-matrix composites (CMCs) under tension-tension cyclic fatigue loading at room and elevated temperatures have been investigated. Fatigue hysteresis loops models considering multiple matrix cracking modes in 2D CMCs have been developed based on the damage mechanism of fiber sliding relative to the matrix in the interface debonded region. The relationships between the fatigue hysteresis loops, fatigue hysteresis dissipated energy, fatigue peak stress, matrix multiple cracking modes, and interface shear stress have been established.

Fatigue Damage and Lifetime of SiC/SiC Ceramic-Matrix Composite under Cyclic Loading at Elevated Temperatures.

In this paper, the fatigue damage and lifetime of 2D SiC/SiC ceramic-matrix composites (CMCs) under cyclic fatigue loading at 750, 1000, 1100, 1200 and 1300 °C in air and in steam atmosphere have been investigated. The damage evolution versus applied cycles of 2D SiC/SiC composites were analyzed using fatigue hysteresis dissipated energy, fatigue hysteresis modulus, fatigue peak strain and interface shear stress. The presence of steam accelerated the damage development inside of SiC/SiC composites, which increased the increasing rate of the fatigue hysteresis dissipated energy and the fatigue peak strain, and the decreasing rate of the fatigue hysteresis modulus and the interface shear stress.

Synergistic Effects of Stress-Rupture and Cyclic Loading on Strain Response of Fiber-Reinforced Ceramic-Matrix Composites at Elevated Temperature in Oxidizing Atmosphere.

In this paper, the synergistic effects of stress rupture and cyclic loading on the strain response of fiber-reinforced ceramic-matrix composites (CMCs) at elevated temperature in air have been investigated. The stress-strain relationships considering interface wear and interface oxidation in the interface debonded region under stress rupture and cyclic loading have been developed to establish the relationship between the peak strain, the interface debonded length, the interface oxidation length and the interface slip lengths. The effects of the stress rupture time, stress levels, matrix crack spacing, fiber volume fraction and oxidation temperature on the peak strain and the interface slip lengths have been investigated.

One-Step Assembly of Phytic Acid Metal Complexes for Superhydrophilic Coatings.

While of immense scientific interest, superhydrophilic surfaces are usually difficult to prepare, and preparation methods are typically substrate specific. Herein, a one-step coating method is described that can endow superhydrophilicity to a variety of substrates, both inorganic and organic, using the coordination complexes of natural phytic acid and Fe(III) ions. Coating deposition occurs in minutes, and coatings are ultrathin, colorless, and transparent.

Modeling Cyclic Fatigue Hysteresis Loops of 2D Woven Ceramic Matrix Composites at Elevated Temperatures in Steam.

In this paper, the cyclic fatigue hysteresis loops of 2D woven SiC/SiC ceramic matrix composites (CMCs) at elevated temperatures in steam have been investigated. The interface slip between fibers and the matrix existing in matrix cracking modes 3 and 5, in which matrix cracking and interface debonding occurred in longitudinal yarns, is considered as the major reason for hysteresis loops of 2D woven CMCs. The hysteresis loops of 2D SiC/SiC composites corresponding to different peak stresses, test conditions, and loading frequencies have been predicted using the present analysis.

Fatigue Life Prediction of Fiber-Reinforced Ceramic-Matrix Composites with Different Fiber Preforms at Room and Elevated Temperatures.

In this paper, the fatigue life of fiber-reinforced ceramic-matrix composites (CMCs) with different fiber preforms, , unidirectional, cross-ply, 2D (two dimensional), 2.5D and 3D CMCs at room and elevated temperatures in air and oxidative environments, has been predicted using the micromechanics approach. An effective coefficient of the fiber volume fraction along the loading direction (ECFL) was introduced to describe the fiber architecture of preforms.

Comparison of Cyclic Hysteresis Behavior between Cross-Ply C/SiC and SiC/SiC Ceramic-Matrix Composites.

In this paper, the comparison of cyclic hysteresis behavior between cross-ply C/SiC and SiC/SiC ceramic-matrix composites (CMCs) has been investigated. The interface slip between fibers and the matrix existed in the matrix cracking mode 3 and mode 5, in which matrix cracking and interface debonding occurred in the 0° plies are considered as the major reason for hysteresis loops of cross-ply CMCs. The hysteresis loops of cross-ply C/SiC and SiC/SiC composites corresponding to different peak stresses have been predicted using present analysis.

Damage Evolution and Life Prediction of Cross-Ply C/SiC Ceramic-Matrix Composite under Cyclic Fatigue Loading at Room Temperature and 800 °C in Air.

The damage evolution and life prediction of cross-ply C/SiC ceramic-matrix composite (CMC) under cyclic-fatigue loading at room temperature and 800 °C in air have been investigated using damage parameters derived from fatigue hysteresis loops, , fatigue hysteresis modulus and fatigue hysteresis loss energy. The experimental fatigue hysteresis modulus and fatigue hysteresis loss energy degrade with increasing applied cycles attributed to transverse cracks in the 90° plies, matrix cracks and fiber/matrix interface debonding in the 0° plies, interface wear at room temperature, and interface and carbon fibers oxidation at 800 °C in air. The relationships between fatigue hysteresis loops, fatigue hysteresis modulus and fatigue hysteresis loss energy have been established.

ADP-ribosylation factor as a novel target for corneal neovascularization regression.

Purpose: To evaluate the roles of ADP-ribosylation factor (ARF) in alkali-induced corneal neovascularization (CNV).

Methods: CNV was induced by alkali injury and compared in ARF1 inhibitor- or vehicle-treated mice 3 weeks after injury. Angiogenic and apoptosis factor expression in corneas after injury was quantified with reverse-transcription PCR.

Inhibitory effect of CCR3 signal on alkali-induced corneal neovascularization.

Aim: To investigate the effect of CC chemokine receptor 3 (CCR3) signal on corneal neovascularization (CRNV) induced by alkali burn and to explore its mechanism.

Methods: Specific pathogen-free male BALB/C mice (aged 6-8 weeks) were randomly divided into CCR3-antagonist treated group (experimental group) and control group. CRNV was induced by alkali burn in mice.