Publications by authors named "Longbi Liu"
Biol Direct
September 2024
Article Synopsis
- Breast cancer (BC) exhibits aggressive behavior and poor prognosis, and this study focuses on the role of Zinc Finger Protein 64 (ZFP64), a transcription factor, in regulating cancer stem-like properties and tumor growth through glycolysis.
- High levels of ZFP64 were found in BC tissues, and patients with elevated ZFP64 had worse survival rates; its expression correlated with various clinical factors like N stage and progesterone receptor status.
- Knocking down ZFP64 reduced BC cell viability and tumor size in animal models, while overexpression of ZFP64 had the opposite effect; it was also shown that ZFP64 influences glycolysis by directly regulating the expression of glycolysis-related genes.
