Publications by authors named "Long-shuan Zhao"
Background: Jujuboside B (JuB) is the main bioactive saponin component of Chinese anti-insomnia herbal medicine Ziziphi Spinosae Semen, which has been reported to possess varied pharmacological functions. Even though it has been traditionally used to treat inflammation- and toxicity-related diseases, the effects of JuB on acetaminophen (APAP) overdose-induced hepatotoxicity have not been determined yet.
Methods: C57BL/6 J mice were pre-treated with JuB (20 or 40 mg/kg) for seven days before APAP (400 mg/kg) injection.
Article Synopsis
- The study aims to evaluate the challenges in accurately diagnosing xanthogranulomatous cholecystitis (XGC) by reviewing 142 pathologically confirmed cases from a hospital over six years.
- Out of these cases, 42 were misdiagnosed as gallbladder carcinoma (GBC), with common presentations including chronic cholecystitis and abnormal imaging findings indicating liver involvement.
- The conclusion highlights that current clinical, laboratory, and imaging techniques are not effective in distinguishing between XGC and GBC, leading to potential misdiagnoses and unnecessary aggressive treatments.
Objective: To study on the efficacy, prognosis and security of high-intensity focused ultrasound (HIFU) combined with transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC).
Methods: Totally 72 HCC patients treated by HIFU from December 2009 to January 2011 were divided into two groups according to treatment methods: 40 cases in HIFU group, 32 cases in TACE + HIFU treatment group (combined group). Then set up a control group include 40 cases treated by only TACE in the same period (TACE group).
Background: Alterations in DNA methylation occur during the pathogenesis of human tumors. In this study, we investigated the influence of DNA methyltransferase 3b (DNMT3b) on fragile histidine trial (FHIT) expression and on DNA methylation of the FHIT promoter region in the hepatoma cell line SMMC-7721.
Methods: DNMT3b siRNA was used to down-regulate DNMT3b expression.
Surgical treatment of 1360 cases of Budd-Chiari syndrome: 20-year experience.
Hepatobiliary Pancreat Dis Int
August 2004
Background: Budd-Chiari syndrome (BCS) is a disease caused by blood flow obstruction of the main hepatic veins (MHVs) and/or the outlet of the inferior vena cava (IVC), characterized by retrohepatic portal hypertension (PHT) and/or IVC hypertension. In the past decade, over 3000 cases of BCS have been reported in China. This study was to sum up our 20-year experience in surgical treatment of BCS and to investigate its pathological classification and principles of surgery.
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