Publications by authors named "Long-Tao Huang"
Sulfondiimines are diaza-analogues of sulfones with a chiral sulfur center. Compared to sulfones and sulfoximines, their synthesis and transformations have so far been studied to a lesser extent. Here, we report the enantioselective synthesis of 1,2-benzothiazine 1-imines, i.
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- - The study discusses the enantioselective C-H alkylation of 8-ethylquinolines using a Rh catalyst and a chiral carboxylic acid, focusing on enones or acrolein as reactants.
- - A specific binaphthyl-based chiral carboxylic acid is used to achieve the selective cleavage of the C(sp)-H bond under mild reaction conditions.
- - The findings highlight the effectiveness of combining a high-valent group 9 metal catalyst with a chiral carboxylic acid for activating C-H bonds and forming C-C bonds in an enantioselective manner.
Article Synopsis
- A new method for creating isatins and isoindigoes using sodium iodide (NaI) is introduced, making the process cost-effective and eco-friendly.
- * The selectivity of the synthesis can be altered by changing the solvent used in the reaction.
- * Using tetrahydrofuran (THF) produces isatins, while dimethyl sulfoxide (DMSO) yields isoindigoes, both achieving moderate to excellent results.
An efficient and practical methodology to obtain α-thio-β-dicarbonyl compounds was presented under alkaline conditions via potassium iodide (KI) catalysis; various symmetrical/unsymmetrical 1,3-dicarbonyl compounds were obtained under an aerobic atmosphere in moderate to excellent yields, with good functional group tolerance. Notably, a widely used anti-inflammatory drug butazodine could be modified with our protocol, even on a gram scale.
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