SIRT2 Mediated Microtubule Acetylation in Osteogenic Differentiation.

Objective: To assess the role of microtubule acetylation in the transportation of amorphous calcium phosphate (ACP)-containing vesicles that mediate the osteogenic differentiation process of rat bone mesenchymal stem cells (BMSCs).

Methods: Rat BMSCs were cultured and transfected with sirtuin 2 (SIRT2) overexpression plasmids for an in vitro model. The microtubule acetylation-related protein levels were detected by western blots.

Nec-1 attenuates inflammation and cytotoxicity induced by high glucose on THP-1 derived macrophages through RIP1.

Objectives: This research aimed to study whether necrostain-1 (Nec-1) could alleviate inflammatory injury induced by high glucose upon THP-1 derived macrophages through RIP1.

Design: Firstly, THP-1 derived macrophages were incubated with 5.5 mM glucose (normal glucose, NG), 25 mM glucose (high glucose, HG), and mannitol as the high osmotic pressure group (5.

Involvement of Programmed Cell Death in Neurotoxicity of Metallic Nanoparticles: Recent Advances and Future Perspectives.

The widespread application of metallic nanoparticles (NPs) or NP-based products has increased the risk of exposure to NPs in humans. The brain is an important organ that is more susceptible to exogenous stimuli. Moreover, any impairment to the brain is irreversible.

Contribution of oxidative stress to TiO nanoparticle-induced toxicity.

With the rapid development of nanotechnology, titanium dioxide nanoparticles (TNPs) are widely used in many fields. People in such workplaces or researchers in laboratories are at a higher risk of being exposed to TNPs, so are the consumers. Moreover, increasing evidence revealed that the concentrations of TNPs are elevated in animal organs after systematic exposure and such accumulated TNPs could induce organ dysfunction.

Is Neurotoxicity of Metallic Nanoparticles the Cascades of Oxidative Stress?

With the rapid development of nanotechnology, metallic (metal or metal oxide) nanoparticles (NPs) are widely used in many fields such as cosmetics, the food and building industries, and bio-medical instruments. Widespread applications of metallic NP-based products increase the health risk associated with human exposures. Studies revealed that the brain, a critical organ that consumes substantial amounts of oxygen, is a primary target of metallic NPs once they are absorbed into the body.

[Effect of pigments concentration on physical and mechanical properties of MDX-4-4210 silicone elastomer].

Purpose: To determine the optimum pigments concentration on the physical and mechanical properties.

Methods: In this study, control samples were prepared from MDX-4-4210 silicone base and tested along with the pigmented samples for comparison in accordance with the national standards. The pigments concentration to base elastomer was set at 0.

[Infinite optical thickness of dentine porcelain of IPS E.max A color series].

Objective: To determine the infinite optical thickness of dentine porcelain of IPS E.max A color series.

Methods: Cylindrical dentine porcelain specimens of the IPS E.

[Effects of three types of veneering porcelain on bending strength of KAVO(TM) Y-TZP/porcelain bilayered structure].

Objective: To investigate the effect of three types of veneering porcelain on the bending strength of KAVO Y-TZP/porcelain layered structure.

Methods: KAVO zirconia ceramics were used as the substructure. To form Y-TZP/porcelain bilayered structure, a leucite-based veneering porcelain was fired on the zirconia substructures by slip-casting technique with dentin washbake, and two nano-fluorapatite-based veneering porcelains were fired on the zirconia substructures by either slip-casting or pressed-on technique with or without liner coverage.

[Effect of pigmentation on the strength of dental Y-TZP/porcelain bilayered structure].

Objective: To investigate the effect of two methods of pigmentation on the flexural strength of dental Y-TZP/porcelain layered structure.

Methods: KaVo zirconia substructures were pigmented by dipping presintered blocks in the coloring solution VITA LL1 and LL5, and colored TZ-3YS zirconia substructures were fabricated by adding pigments before isostatic pressing. The colors No.

[Measurement of chromaticity of five hued zirconia].

Objective: To determine the chroma value of sintered IL1-IL5 zirconia materials in comparison with the Vita In-Ceram YZ color shade.

Methods: Five types of shading dental zirconia ceramics with color gradient were prepared by adding Fe2O3, CeO2, and Bi2O3 to the zirconia powder, and their chroma values were determined using a spectrophotometer and the color difference was calculated.

Results: The chroma value ranges were L: 67.