Publications by authors named "Long-Kun Wang"
Edwardsiella piscicida is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish. The type III secretion system (T3SS) is one of its two most important virulence islands. T3SS protein EseJ inhibits E.
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- Edwardsiella ictaluri is a harmful bacteria that causes diseases in channel catfish, leading to big money losses for fish farmers in China.
- Scientists created a weaker version of this bacteria by changing some of its genes, making it unable to infect cells properly, and it can be used as a vaccine.
- The new vaccine worked really well, keeping 83.61% of vaccinated fish alive after exposure to the harmful bacteria, compared to only 33.33% survival in unvaccinated fish.
Aberrant activation of CYR61 enhancers in colorectal cancer development.
J Exp Clin Cancer Res
May 2019
Background: High expression of secreted matricellular protein cysteine-rich 61 (CYR61) correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer activation has been shown to correlate with expression of key genes involved in cancer progression. However, such mechanisms in CYR61 transcription regulation remain unexplored.
View Article and Find Full Text PDFHMGB3 belongs to the high-mobility group box subfamily and has been found to be overexpressed in gastric cancer. However, the expression and the role of HMGB3 in human hepatocellular carcinoma remain unknown. Here, we report that HMGB3, which is suppressed by miR-200b, contributes to cell proliferation and migration in human hepatocellular carcinoma.
View Article and Find Full Text PDFBackground: Actinidia chinensis Planch, which is distributed only in China, has been used to treat hepatitis and cancer. The objective of the present work was to identify the antiviral active ingredient of A. chinensis root bark (ACRB).
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