miR-576-5p Promotes the Proliferation of Papillary Thyroid Carcinoma through the MAPK4-AKT Pathway.

Background: MicroRNA-576-5p (miR-576-5p) plays an important role in different human cancers. However, the biological function of miR-576-5p in papillary thyroid carcinoma (PTC) is still unclear. In this study, we explored the function and specific role of miR-576-5p in PTC.

A Speech Enhancement Algorithm for Speech Reconstruction Based on Laser Speckle Images.

In the optical system for reconstructing speech signals based on laser speckle images, the resonance between the sound source and nearby objects leads to frequency response problem, which seriously affects the accuracy of reconstructed speech. In this paper, we propose a speech enhancement algorithm to reduce the frequency response. The results show that after using the speech enhancement algorithm, the frequency spectrum correlation coefficient between the reconstructed sinusoidal signal and the original sinusoidal signal is improved by up to 82.

Design and Optimization of High-Power and Low-Frequency Broadband Transducer with Giant Magnetostrictive Material.

The applications of sensors in the aerospace industry are mostly concentrated in the middle and high frequencies, and low-frequency sensors often face the problems of low power and short working bandwidth. A lightweight, thin, high-power, low-frequency broadband transducer based on giant magnetostrictive material is designed. The design and optimization processes of the core components are introduced and analyzed emphatically.

ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner.

The asparaginase-like protein 1 (ASRGL1) catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Emerging evidences have shown a strong correlation between ASRGL1 expression and tumorigenesis. However, the expression and biological function of ASRGL1 in hepatocellular carcinoma (HCC) are still unclear.

Effects of Genetic Variation of the Sorting Nexin 29 () Gene on Growth Traits of Xiangdong Black Goat.

Previous studies have found that the copy number variation (CNV) and insertion/deletion (indels) located in the sorting nexin 29 (SNX29) gene, which is an important candidate gene related to meat production and quality, are associated with growth traits of African goats and Shaanbei white cashmere goats. However, the genetic effects of SNX29 genetic variation on growth traits of Xiangdong black (XDB) goat (a representative meat goat breed in China) are still unclear. The purpose of this study was to detect the mRNA expression level of SNX29 and to explore the genetic effects of CNV and indel within SNX29 on growth traits and gene expression in XDB goat.

IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat Orthotopic Liver Transplantation Model.

Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological action of IL-18 due to its high concentration and high affinity, thus preventing the production of IFN-γ and inhibiting NK-cell activation. Through previous studies and the phenomena observed by our group in pig-non-human primates (NHPs) liver transplantation experiments, we proposed that the imbalance in IL-18/IL-18BP expression upon transplantation encourages the activation, proliferation, and cytotoxic effects of NK cells, ultimately causing acute vascular rejection of the graft.

Cloning and Molecular Characterization of Coding for Oxalate Decarboxylase in the Mycoparasite .

() is a mycoparasitic fungus of (), the causal agent of Sclerotinia stem rot of oilseed rape. can produce oxalic acid (OA) as a phytotoxin, whereas can degrade OA, thereby nullifying the toxic effect of OA. Two oxalate decarboxylase (OxDC)-coding genes, and , were cloned, and only was found to be partially responsible for OA degradation, implying that other OA-degrading genes may exist in .

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis.

Background: Type I interferon (IFN) inhibits virus infection through multiple processes. Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the cellular metabolism. The sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1), as an interferon-stimulated gene (ISG), has been reported to inhibit a number of retroviruses and DNA viruses, by depleting dNTPs indispensable for viral DNA replication.

Orally administered MOTS-c analogue ameliorates dextran sulfate sodium-induced colitis by inhibiting inflammation and apoptosis.

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract (GI). Currently, the treatment options for IBD are limited. It has been reported that a novel bioactive mitochondrial-derived peptide (MOTS-c) encoded in the mitochondrial 12S rRNA, suppresses inflammatory response by enhancing the phagocytosis of macrophages.

The short-long-short-short sequence and polymorphic ventricular tachycardias storm.

We described a case of a patient who developed repetitive episodes of polymorphic ventricular tachycardias with a stereotypical pattern of initiation. A short-long-short-short (S-L-S-S) cardiac cycle sequence preceded all episodes and was considered to be the underlying initiative mechanism for these fatal arrhythmic events. In the patient, the paroxysmal atrial fibrillation was responsible for S-L-S-S sequence.

Defectronics based photoelectrochemical properties of Cu ion doped hematite thin film.

The concentration of guest elements (dopants) into host materials play an important role in changing their intrinsic electrical and optical properties. The existence of hetero-element induce defect in crystal structure, affecting conductivity. In the current work, we report Cu ion into hematite in the defectronics point of view and their photoelectrochemical properties.

Precise Patellar Tendon Insertion Protection and Osteotomy Surface Advantage of Transtibial Tuberosity-High Tibial Osteotomy.

Objective: Medial opening wedge high tibial osteotomy (HTO) is successful in the treatment of knee osteoarthritis with medial compartment stenosis and tibial varus deformity, but patella infera is the main complication. This study aims to design a new medial tibial open osteotomy scheme, transtibial tuberosity-high tibial osteotomy (TT-HTO), which can fully protect the patellar tendon insertion. In addition, the area of the osteotomy surface and wedge volume were evaluated in TT-HTO, biplanar distal tibial tuberosity osteotomy (biplanar-DTO), and uniplanar-DTO to evaluate the potential advantages of this technology in bone healing.

Clinical observation of radiofrequency ablation for premature ventricular contractions originating from uncommon His-Purkinje sites.

Background: Radiofrequency catheter ablation (RFCA) of premature ventricular contractions (PVCs) originating from common locations such as the proximal and middle fascicles of the His-Purkinje system (HPS) has been established as an effective therapy. This report aims to highlight the electrophysiological properties and RFCA of PVCs originating from uncommon locations of the HPS.

Methods: Among 57 patients with fascicular PVCs, 3 with fascicular PVCs originating from uncommon sites were retrospectively analyzed.

Noninvasive Prediction of Ki-67 Expression in Hepatocellular Carcinoma Using Machine Learning-Based Ultrasomics: A Multicenter Study.

Objectives: To investigate the ability of ultrasomics to predict Ki-67 expression in hepatocellular carcinoma (HCC).

Methods: A total of 244 patients from three hospitals were retrospectively recruited (training dataset, n = 168; test dataset, n = 43; and validation dataset, n = 33). Lesion segmentation of the ultrasound images was performed manually by two radiologists.

Genomic signals of local adaptation and hybridization in Asian white birch.

Disentangling the numerous processes that affect patterns of genome-wide diversity in widespread tree species has important implications for taxonomy, conservation, and forestry. Here, we investigate the population genomic structure of Asian white birch (Betula platyphylla) in China and seek to explain it in terms of hybridization, demography and adaptation. We generate whole genome sequence data from 83 individuals across the species range in China.

Optimize the combination regimen of Trastuzumab and Nab-paclitaxel in HER2-positive tumors via modulating Caveolin-1 expression by lovastatin.

The combination regimen of trastuzumab (Tras) plus Nab-paclitaxel (Nab) is recommended to treat HER2-positive (HER2) cancers. However, they exert effects in different mechanisms: Tras need to stay on cell membranes, while Nab need to be endocytosed, therefore the concurrent combination regimen may not be the best one in HER2 tumors treatment. Caveolin-1 (Cav-1) is a key player in mediating their endocytosis and is associated with their efficacy, but few researches noticed the opposite effect of Cav-1 expression on the combination efficacy.

Construction of a cellulose-based high-performance adhesive with a crosslinking structure bridged by Schiff base and ureido groups.

Biomass-based adhesives are considered to be the preferred alternative to formaldehyde-type wood adhesives due to their wide range of sources, low cost, and sustainability. Herein, an environmentally friendly Schiff base cross-linked compact three-dimensional network structure bio-adhesive (DAC-PEI-U) derived from polyethyleneimine (PEI), urea, and cellulose was successfully prepared, verifying by detailed FTIR, NMR, and XPS analysis. Schiff base bridging between aldehyde groups in dialdehyde cellulose (DAC) and amino groups in polyurea (PEIU) not only constructed crosslinking networks but also endowed adhesives with good adhesion property.

3D deep learning versus the current methods for predicting tumor invasiveness of lung adenocarcinoma based on high-resolution computed tomography images.

Background: Different pathological subtypes of lung adenocarcinoma lead to different treatment decisions and prognoses, and it is clinically important to distinguish invasive lung adenocarcinoma from preinvasive adenocarcinoma (adenocarcinoma and minimally invasive adenocarcinoma). This study aims to investigate the performance of the deep learning approach based on high-resolution computed tomography (HRCT) images in the classification of tumor invasiveness and compare it with the performances of currently available approaches.

Methods: In this study, we used a deep learning approach based on 3D conventional networks to automatically predict the invasiveness of pulmonary nodules.

Hierarchical medical system and local medical performance: A quasi-natural experiment evaluation in Shanghai, China.

Background: In order to maintain high standards of healthcare, it is necessary for medical departments to provide high-quality and affordable medical services to local residents. This has been widely accepted in developed countries, while the medical treatment systems in developing countries remain to be improved. This research is based on a pilot of a hierarchical medical system in Shanghai, China, to evaluate the effects on policy of medical reform in developing countries.

Predictive Value of Combination of Procalcitonin and Predisposition, Infection, Response, and Organ Dysfunction (PIRO) System in Septic Patients with Positive Blood Cultures in the Emergency Department.

Purpose: Procalcitonin and predisposition, infection, response, and organ dysfunction (PIRO) system have high predictive value for the prognosis of critically ill patients. There are few studies on the predictive value of patients with positive blood cultures. The aim of the study was to evaluate risk stratification and sepsis-related mortality in patients with positive blood cultures via procalcitonin (PCT) combined with the PIRO system in emergency departments (ED).

Crim1 inhibits angiotensin II-induced hypertrophy and preserves Kv4.2 expression in cardiomyocytes.

Objectives: Angiotensin II (Ang II) plays a key role in the regulation of myocardial hypertrophy via downstream cysteine-rich transmembrane bone morphogenetic protein regulator 1 (Crim1). However, it is still unclear whether Crim1 is involved in ionic channel remodeling. The study aimed to explore the effects of Crim1 on transient outward potassium current (Ito) and Kv4.