Recent advances in copper homeostasis-involved tumor theranostics.

As the third essential trace element in the human body, copper plays a crucial role in various physiological processes, which lays the foundation for its broad applications in cancer treatments. The overview of copper, including pharmacokinetics, signaling pathways, and homeostasis dysregulation, is hereby discussed. Additionally, cuproptosis, as a newly proposed cell death mechanism associated with copper accumulation, is analyzed and further developed for efficient cancer treatment.

Phase Stability of CH and CO Hydrates under Confinement Predicted by Machine Learning.

Understanding the phase stability of gas hydrates under confinement is fundamental to the geological stability evolutions of gas hydrate systems on Earth. Herein, the phase stability of CH and CO hydrates under confinement is predicted by machine learning. Three machine learning models, including support vector machine, random forest, and gradient boosting decision tree, are constructed to predict the phase stability of CH and CO hydrates under confinement.

Hyperspectal imaging technology for phenotyping iron and boron deficiency in under greenhouse conditions.

Introduction: The micronutrient deficiency of iron and boron is a common issue affecting the growth of rapeseed (). In this study, a non-destructive diagnosis method for iron and boron deficiency in (genotype: Zhongshuang 11) using hyperspectral imaging technology was established.

Methods: The recognition accuracy was compared using the Fisher Linear Discriminant Analysis (LDA) and Support Vector Machine (SVM) recognition models.

Strength-ductility materials by engineering a coherent interface at incoherent precipitates.

In the quest for excellent light-structural materials that can withstand mechanical extremes for advanced applications, design and control of microstructures beyond current material design strategies have become paramount. Herein, we design a coherent shell at incoherent precipitates in the 2195 aluminum alloy with multi-step metastable phase transitions. A high local strain rate a neoteric deformation-driven metallurgy method facilitated the diffusion of Li.

Effect of electroacupuncture on myocardial electrical remodeling in rats with acute myocardial infarction.

Objectives: To investigate the mechanism of electroacupuncture (EA) at "Neiguan" (PC6) in impro-ving myocardial electrical remodeling in rats with acute myocardial infarction (AMI) by enhancing transient outward potassium current.

Methods: A total of 30 male SD rats were randomly divided into control, model and EA groups, with 10 rats in each group. The AMI model was established by subcutaneous injection with isoprenaline (ISO, 85 mg/kg).

[Clinical and genetic analysis of a patient with Loeys-Dietz syndrome due to variant of TGFBR2 gene].

Objective: To explore the genetic basis of a patient with clinically suspected Loeys-Dietz syndrome (LDS).

Methods: A child who had presented at Beijing Anzhen Hospital in September 2018 was selected as the study subject. Clinical data and family history of the patient were collected, along with peripheral blood samples of the proband and his parents.

Attachment of facile synthesized NaCoO nanodots to SiO nanoflakes for sodium-rich boosted Pt-dominated ambient HCHO oxidation.

Surface alkali metal ions are typically utilized as available promoters for ambient HCHO oxidation. In this study, NaCoO nanodots with two different preferential crystallographic orientations are synthesized by facile attachment to SiO nanoflakes with varying degrees of lattice defects. A unique Na-rich environment is established through interlayer Na diffusion based on the small size effect.

LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein.

Long noncoding RNAs (lncRNAs) have been shown to contribute to tumorigenesis and cancer progression. However, neither the dysregulation nor the functions of anti-sense lncRNAs in papillary thyroid carcinoma (PTC) have been exhaustively studied. In this study, we accessed The Cancer Genome Atlas (TCGA) database and discovered that the natural antisense lncRNA SOCS2-AS1 is highly expressed in PTC and that patients with a higher level of SOCS2-AS1 had a poor prognosis.

Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis.

Background: Breast cancer is one of the most malignant cancers. Increasing evidence suggests that circular RNAs (circRNAs) are involved in breast cancer progression through sponging microRNA (miRNA). However, the underlying molecular mechanisms of circ_0069094 in breast cancer are unclear.

A Self-Healing Gel Polymer Electrolyte, Based on a Macromolecule Cross-Linked Chitosan for Flexible Supercapacitors.

Gel polymer electrolytes with a satisfied ionic conductivity have attracted interest in flexible energy storage technologies, such as supercapacitors and rechargeable batteries. However, the poor mechanical strength inhibits its widespread application. One of the most significant ways to avoid the drawbacks of the gel polymer electrolytes without compromising their ion transportation capabilities is to create a self-healing structure with the cross-linking segment.

Constructing a drug release model by central composite design to investigate the interaction between drugs and temperature-sensitive controlled release nanoparticles.

To study the release behavior of a thermosensitive controlled release drug delivery system and construct a predictable mathematical model of drug release, poly(N-isopropylacrylamide-co-Allylamine) (P(NIPA-AL17)) and ploy(styrene sulfonate) (PSS) were functionalized on the surface of hollow mesoporous carbon nanoparticles (HMCNs) through layer-by-layer (LBL) assembly to construct a photothermal responsive controlled release system. A five-level four-factorial central composite design (CCD) was performed to investigate the relationship between four independent variables including drug loading (A), number of polymer layers (B), temperature (C) and vibration rate of the shaker (D), and three dependent response variables, including cumulative release over 1 h (Y), cumulative release over 24 h (Y) and the release rate constant k (Y). The CCD results indicate that A and C significantly affect Y (P < 0.

Effects of electroacupuncture on rats with cognitive impairment: An iTRAQ-based proteomics analysis.

Objective: The study explores the effects of electroacupuncture (EA) at the governing vessel (GV) on proteomic changes in the hippocampus of rats with cognitive impairment.

Methods: Healthy male rats were randomly divided into 3 groups: sham, model and EA. Cognitive impairment was induced by left middle cerebral artery occlusion in the model and EA groups.

Effect of Temperature and Material Flow Gradients on Mechanical Performances of Friction Stir Welded AA6082-T6 Joints.

The temperature and material flow gradients along the thick section of the weld seriously affect the welding efficiency of friction stir welding in medium-thick plates. Here, the effects of different gradients obtained by the two pins on the weld formation, microstructure, and mechanical properties were compared. The results indicated that the large-tip pin increases heat input and material flow at the bottom, reducing the gradient along the thickness.

Case report: Quadruple primary malignant neoplasms including esophageal, ureteral, and lung in an elderly male.

Multiple primary malignant neoplasms (MPMNs) are defined as multiple tumors with different pathogenic origins. MPMNs are rare, but the morbidity rate is on the rise. With the development of anti-tumor treatments, such as targeted therapy and immunotherapy, the overall survival of cancer patients has been significantly prolonged, leading to an increased number of patients with MPMNs.

Grain Boundary Engineering in Ta-Doped Garnet-Type Electrolyte for Lithium Dendrite Suppression.

Solid-state lithium batteries (SSLBs) based on Ta-doped LiLaZrTaO (LLZTO) suffer from lithium dendrite growth, which hinders their practical application. Herein, first principles simulations indicate that the Ta element prefers to segregate along grain boundaries in the form of TaO precipitates due to a high energy difference induced by Ta doping. Grain boundary engineering is employed to regulate the distribution of the Ta element and enhance the density of LLZTO by introducing the LaO additive.

Interface Formation of Medium-Thick AA6061 Al/AZ31B Mg Dissimilar Submerged Friction Stir Welding Joints.

The medium-thick Al/Mg dissimilar friction stir welding (FSW) joint has serious groove and cavity defects due to uneven thermal distribution in the thickness direction. The submerged friction stir welding (SFSW) was employed to decrease the peak temperature of the joint and control the thermal gradient of the thickness direction, which were beneficial in suppressing the coarsening of the intermetallic compounds (IMCs) layer and improving the weld formation. According to the SEM results, the thickness value of the IMC layer in the nugget zone and shoulder affect zone decreased from 0.

Application of Contrast-Enhanced Ultrasound Combined with Elastic Imaging Technology in Differential Diagnosis of Salivary Gland Tumors.

This paper proposes the effect of contrast-enhanced ultrasound combined with real-time elastic imaging technology in the differential diagnosis of salivary gland tumors. 200 patients were selected, including 120 males and 60 females. The age ranged from 9 to 83 years, with an average of 55.

Plant interactions control the carbon distribution of Dodonaea viscosa in karst regions.

Biomass and carbon (C) distribution are suggested as strategies of plant responses to resource stress. Understanding the distribution patterns of biomass and C is the key to vegetation restoration in fragile ecosystems, however, there is limited understanding of the intraspecific biomass and C distributions of shrubs resulting from plant interactions in karst areas. In this study, three vegetation restoration types, a Dodonaea viscosa monoculture (DM), a Eucalyptus maideni and D.

Synergy of surface sodium and hydroxyl on NaTiHO nanotubes accelerating the Pt-dominated ambient HCHO oxidation.

Surface hydroxyl is widely perceived as conducive to HCHO degradation. Here, a kind of sodium titanate with interlayered hydroxyls (NaTiHO) was prepared to study the action conditions of surface hydroxyls in HCHO oxidation. The nanotubes mainly exposing (001) and nanobelts mainly exposing (100) are synthesized as the two morphologies of NaTiHO.

Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis.

Some circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of breast cancer (BC). We aimed to investigate the role of circRNA trefoil factor 1 (circ-TFF1) in BC progression. The expression of circ-TFF1, microRNA-338-3p (miR-338-3p) and fibroblast growth factor receptor 1 (FGFR1) mRNA was measured by quantitative real-time polymerase chain reaction (qRT-PCR).

Homogeneously Dispersed Graphene Nanoplatelets as Long-Term Corrosion Inhibitors for Aluminum Matrix Composites.

Deformation-driven metallurgy was implemented to prepare graphene nanoplatelet (GNP)-reinforced aluminum matrix composites with a time-dependent self-enhancement in corrosion resistance. Severe plastic deformation contributed to the sufficient brokenness, thinning, enfolding, and redispersion of GNPs, as well as grain refinement. The homogeneously dispersed GNPs showed a great corrosion inhibition mechanism in a chloride-containing environment, ascribed to the formation of a carbon-doped protective film via diffusion and chemical bonding between GNPs and the surface oxide film.

Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment.

Diabetes mellitus is a major threat to human health. Both its incidence and prevalence have been rising steadily over the past few decades. Biomacromolecular agents such as insulin and glucagon-like peptide 1 receptor agonists are commonly used hypoglycemic drugs that play important roles in the treatment of diabetes.

Rising resistance of urinary tract pathogens in children: a cause for concern.

Background: Urinary tract infection (UTI) is one of the common infections in childhood. Prompt diagnosis and treatment reduces the risk of complications. The choice of antibiotic to treat UTI varies from region to region.