Publications by authors named "Long Sun"

Purpose: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts and certain tumor cells, making it a promising therapeutic target for various malignancies. This study evaluated the efficacy and safety of 177Lu-Evans blue-FAP inhibitor (177Lu-LNC1004) radioligand therapy (RLT) for treating end-stage metastatic tumors.

Patients And Methods: This single-arm, single-center, phase II trial included 28 patients with progressive metastatic malignancies (11 types) and high FAP expression (defined as a maximum standardized uptake value ≥10 in >50% of tumors) who had exhausted all approved therapies, screened between June 2022 and April 2024.

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Metal ion-doped organic-inorganic hybrid metal halides have emerged as promising room-temperature phosphorescence (RTP) materials owing to their tunable afterglow properties and significant potential in information security applications. However, optimizing RTP performance and achieving dynamic control over afterglow colors remain challenging in 1D hybrid systems, primarily because of the inefficient energy transfer from RTP-active organic components to external emissive sites. Herein, we report a novel 1D hybrid metal halide benchmark material, [(NBP)CdClHO] (NBP-Cd, NBP = -benzylpiperidone), and a series of Mn-doped derivatives, NBP-Cd:Mn (where represents doping levels from 1% to 50%).

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Objective: This study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery.

Methods: 96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min.

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Farming activities contribute to soil antibiotic pollution, posing health risks for rural farm workers, especially on small farms in impoverished regions. The effectiveness of large farms in reducing poverty-induced soil antibiotic exposure risk (SABER) remains uncertain. Here we integrate global datasets on concentration of soil antibiotics, rural farm-worker employments and on-farm working hours to quantify SABER.

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Background: Cisplatin (DDP) is a commonly utilized chemotherapeutic agent. Nevertheless, the development of resistance to DDP significantly diminishes the effectiveness of DDP-based chemotherapy in patients with non-small cell lung cancer (NSCLC). In this study, we investigated the impact of endothelin 1 (EDN1) on the resistance to DDP in NSCLC.

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Global warming increases the freeze-thaw (FT) cycles, however, the impact of increased FT cycles on the environmental behavior of arsenic (As) in soils and the toxic effect of As to microorganisms are still unknown. Herein, the influence of FT cycles on As forms, available As, and microbial community structure in paddy soils was investigated. After 60 FT cycles, the content of exchangeable As and residual state As decreased by 1.

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Foul-smelling organic sulfur gases removal of which is crucial for improving environmental quality and protecting human health. Herein, in this study, Pt single-atom (SA) loaded magnesium oxide (MgO) nanosheet catalysts were prepared, which exhibited the dual effects of anchored sulfur and activated oxygen that greatly enhanced the catalytic oxidation efficiency of methyl mercaptan (CHSH), and 90 % complete oxidation of CHSH could be achieved by Pt SA/MgO at 325 °C, with an oxidation efficiency that was 8 times higher than that of MgO nanosheets. A series of characterization results indicate that the valence state of Pt in the Pt SA/MgO catalyst ranges between 0 and +4, demonstrating its inherent electron-donating capability.

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Background: Helicobacter pylori (H. pylori) infection promotes gastric cancer (GC) through various mechanisms. It causes inflammation and damage to the gastric mucosa, thereby increasing the risk of developing GC.

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Purpose: To evaluate the diagnostic accuracy and clinical impact of fibroblast activation protein (FAP)-targeted PET/CT imaging in primary and metastatic breast cancer and compare the results with those of standard-of-care imaging (SCI) and [F]FDG PET/CT.

Methods: We prospectively analyzed patients with diagnosed or suspected breast cancer who underwent concomitant FAP-targeted PET/CT (radiotracers including either [Ga]Ga-FAPI-46 or [F]FAPI-42) and [F]FDG PET/CT scans from June 2020 to January 2024 at two medical centers. Breast ultrasound (US) imaging was performed in all treatment-naïve patients as SCI.

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Climate change and human activity are increasing the frequency of wildfires in peatlands and threatening permafrost peatland carbon pools. In Northeast China, low-severity prescribed fires are conducted annually on permafrost peatlands to reduce the risk of wildfires. These fires typically do not burn surface peat but lead to the loss of surface vegetation and introduction of pyrogenic carbon.

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Detecting trace amounts of aflatoxin B (AFB), one of the most toxic food contaminants, is crucial for efficiently preventing potential health risks. Circular aptamers are promising candidates for bioanalytical applications due to their enhanced biological and structural stability as well as their compatibility with rolling circle amplification (RCA). Herein, we employed a high-efficiency magnetic chain graphene oxide-based SELEX to generate circular aptamers that bind AFB with high affinity and selectivity.

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Factor XIa (FXIa) is a plasma protease that catalyzes the intrinsic pathway of blood coagulation, thus being regarded as a promising antithrombotic target. Circular DNA aptamers, with their dramatically enhanced biological and structural stability, hold great potential as new-generation DNA-based anticoagulants. However, the functional selection of circular aptamers and large-scale synthesis of them remains a substantial challenge.

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Background: Fibroblast activation protein (FAP)-targeted radioligand therapy, with immunomodulatory effects, has shown efficacy in both preclinical and clinical studies. We recently reported on a novel dimeric FAP-targeting radiopharmaceutical, Ga/Lu-DOTA-2P(FAPI), which demonstrated increased tumor uptake and prolonged retention in various cancers. However, further exploration is required to understand the therapeutic efficacy and underlying mechanisms of combining Ga/Lu-DOTA-2P(FAPI) radioligand therapy with PD-1/PD-L1 immunotherapy.

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The air film thickness is an important parameter of an air cushion belt conveyor, which directly affects the compressed air supply power and operating resistance of the system. Therefore, it is important to calculate the bottom thickness of the gas film accurately in the design stage. A calculation method for the thickness of a conveyor air cushion was derived based on the mathematical model of the air cushion flow field for a multi row uniformly distributed air cushion structure.

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Purpose: Workplace violence (WPV) against healthcare workers is a significant public health issue in China and globally. Although the effort-reward imbalance theory claimed that work rewards may moderate the relationship between work effort and WPV, the quantitative evidence is limited. This study aimed to examine if work reward could moderate the associations between work effort and WPV against medical staff based on the effort-reward imbalance theory.

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This study compared Ga-FAPI-46 PET/CT, F-fluorodeoxyglucose (FDG) PET/CT, and contrast-enhanced MRI (CE-MRI) for glioma imaging, classification, and recurrence detection and explored PET parameters and molecular pathological profiles. Between June 2020 and June 2024, we prospectively enrolled patients with space-occupying lesions in the brain or previously treated gliomas. All patients underwent sequential CE-MRI, Ga-FAPI-46, and F-FDG PET/CT.

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Osteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly.

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BACKGROUNDConsidering that trophoblast cell-surface antigen 2 (Trop2) is overexpressed in a wide range of human epithelial cancers, it presents an attractive target for diagnosis and treatment of multiple types of cancer. Herein, we have developed a Trop2-specific radiotracer, 68Ga-MY6349, and present a prospective, investigator-initiated trial to explore the clinical value of 68Ga-MY6349 PET/CT.METHODSIn this translational study, 90 patients with 15 types of cancer who underwent 68Ga-MY6349 PET/CT were enrolled prospectively.

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In the realm of oil-water separation technologies, membrane-based separation emerges as an efficacious approach. Nevertheless, crafting a hydrophilic membrane capable of effectively segregating herbal volatile oil remains a formidable challenge. Our study introduces a facile in situ assembly strategy for fabricating a double-crosslinked composite coating comprising phytate (PA)-polyethyleneimine (PEI) polyelectrolyte complexes and PA-Fe⁺ assemblies.

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Profenofos, as a typical chiral organophosphorus pesticide, can cause various environmental problems and even endanger human health when used in excess. The toxicity of chiral profenofos was investigated through multispectral analysis, molecular docking, and density functional theory (DFT), employing human serum albumin (HSA) as the model protein. Fluorescence titration and lifetime measurements demonstrated that the interaction between chiral profenofos and HSA involves static quenching.

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Article Synopsis
  • This study investigated the risk factors for the progression of asymptomatic penetrating aortic ulcers (PAUs) in patients diagnosed incidentally through imaging.
  • Out of 60 patients, 32 (53.33%) showed progression of their PAUs, with a significant correlation found between the use of antineoplastic therapy and PAU progression.
  • The study recommends increased monitoring for patients on antineoplastic therapy, suggesting it may increase the risk of PAU progression.
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Synopsis of recent research by authors named "Long Sun"

  • - Long Sun's recent research focuses on environmental science and health, exploring efficient separation methods for oils, the interaction between pesticides and proteins, and impacts on water quality and soil management.
  • - Key findings include the successful development of hydrophilic PVDF membranes for separating herbal volatile oils and the investigation of chiral profenofos toxicity through its binding mechanisms with human serum albumin.
  • - Additional studies cover the influence of freeze-thaw cycles on arsenic mobility in paddy soils, the role of biochar in regulating soil carbon stability, and the diverse factors affecting stream water quality across various landscapes.

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