177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study.

Purpose: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts and certain tumor cells, making it a promising therapeutic target for various malignancies. This study evaluated the efficacy and safety of 177Lu-Evans blue-FAP inhibitor (177Lu-LNC1004) radioligand therapy (RLT) for treating end-stage metastatic tumors.

Patients And Methods: This single-arm, single-center, phase II trial included 28 patients with progressive metastatic malignancies (11 types) and high FAP expression (defined as a maximum standardized uptake value ≥10 in >50% of tumors) who had exhausted all approved therapies, screened between June 2022 and April 2024.

Efficient energy transfer from organic triplet states to Mn dopants for dynamic tunable multicolor afterglow in 1D hybrid cadmium chloride.

Metal ion-doped organic-inorganic hybrid metal halides have emerged as promising room-temperature phosphorescence (RTP) materials owing to their tunable afterglow properties and significant potential in information security applications. However, optimizing RTP performance and achieving dynamic control over afterglow colors remain challenging in 1D hybrid systems, primarily because of the inefficient energy transfer from RTP-active organic components to external emissive sites. Herein, we report a novel 1D hybrid metal halide benchmark material, [(NBP)CdClHO] (NBP-Cd, NBP = -benzylpiperidone), and a series of Mn-doped derivatives, NBP-Cd:Mn (where represents doping levels from 1% to 50%).

Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial.

Objective: This study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery.

Methods: 96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min.

Optimal farm size reduces global poverty-induced soil antibiotic exposure risk.

Farming activities contribute to soil antibiotic pollution, posing health risks for rural farm workers, especially on small farms in impoverished regions. The effectiveness of large farms in reducing poverty-induced soil antibiotic exposure risk (SABER) remains uncertain. Here we integrate global datasets on concentration of soil antibiotics, rural farm-worker employments and on-farm working hours to quantify SABER.

Erratum: Data-driven evaluation of electric vehicle energy consumption for generalizing standard testing to real-world driving.

[This corrects the article DOI: 10.1016/j.patter.

EDN1 facilitates cisplatin resistance of non-small cell lung cancer cells by regulating the TNF signaling pathway.

Background: Cisplatin (DDP) is a commonly utilized chemotherapeutic agent. Nevertheless, the development of resistance to DDP significantly diminishes the effectiveness of DDP-based chemotherapy in patients with non-small cell lung cancer (NSCLC). In this study, we investigated the impact of endothelin 1 (EDN1) on the resistance to DDP in NSCLC.

Influence of freeze-thaw cycles on change of arsenic speciation and toxic effects to bacteria in paddy soil.

Global warming increases the freeze-thaw (FT) cycles, however, the impact of increased FT cycles on the environmental behavior of arsenic (As) in soils and the toxic effect of As to microorganisms are still unknown. Herein, the influence of FT cycles on As forms, available As, and microbial community structure in paddy soils was investigated. After 60 FT cycles, the content of exchangeable As and residual state As decreased by 1.

Dual effect of anchored sulphur and activated oxygen in the catalytic oxidation of organic sulfur over Pt single-atom catalysts.

Foul-smelling organic sulfur gases removal of which is crucial for improving environmental quality and protecting human health. Herein, in this study, Pt single-atom (SA) loaded magnesium oxide (MgO) nanosheet catalysts were prepared, which exhibited the dual effects of anchored sulfur and activated oxygen that greatly enhanced the catalytic oxidation efficiency of methyl mercaptan (CHSH), and 90 % complete oxidation of CHSH could be achieved by Pt SA/MgO at 325 °C, with an oxidation efficiency that was 8 times higher than that of MgO nanosheets. A series of characterization results indicate that the valence state of Pt in the Pt SA/MgO catalyst ranges between 0 and +4, demonstrating its inherent electron-donating capability.

SphK2 promotes the progression of Helicobacter pylori-positive gastric cancer by regulating the Ras/MEK/ERK pathway.

Background: Helicobacter pylori (H. pylori) infection promotes gastric cancer (GC) through various mechanisms. It causes inflammation and damage to the gastric mucosa, thereby increasing the risk of developing GC.

FAP-targeted PET/CT imaging in patients with breast cancer from a prospective bi-center study: insights into diagnosis and clinic management.

Purpose: To evaluate the diagnostic accuracy and clinical impact of fibroblast activation protein (FAP)-targeted PET/CT imaging in primary and metastatic breast cancer and compare the results with those of standard-of-care imaging (SCI) and [F]FDG PET/CT.

Methods: We prospectively analyzed patients with diagnosed or suspected breast cancer who underwent concomitant FAP-targeted PET/CT (radiotracers including either [Ga]Ga-FAPI-46 or [F]FAPI-42) and [F]FDG PET/CT scans from June 2020 to January 2024 at two medical centers. Breast ultrasound (US) imaging was performed in all treatment-naïve patients as SCI.

Effects of Low-Severity Fire on the Composition and Stability of Soil Organic Carbon in Permafrost Peatlands (Northeast China).

Climate change and human activity are increasing the frequency of wildfires in peatlands and threatening permafrost peatland carbon pools. In Northeast China, low-severity prescribed fires are conducted annually on permafrost peatlands to reduce the risk of wildfires. These fires typically do not burn surface peat but lead to the loss of surface vegetation and introduction of pyrogenic carbon.

Selection of High-Affinity and Selectivity AFB Circular Aptamer for Biosensor Application.

Detecting trace amounts of aflatoxin B (AFB), one of the most toxic food contaminants, is crucial for efficiently preventing potential health risks. Circular aptamers are promising candidates for bioanalytical applications due to their enhanced biological and structural stability as well as their compatibility with rolling circle amplification (RCA). Herein, we employed a high-efficiency magnetic chain graphene oxide-based SELEX to generate circular aptamers that bind AFB with high affinity and selectivity.

Binding-Site Directed Selection and Large-Scale Click-Synthesis of a Coagulation Factor XIa-Inhibiting Circular DNA Aptamer.

Factor XIa (FXIa) is a plasma protease that catalyzes the intrinsic pathway of blood coagulation, thus being regarded as a promising antithrombotic target. Circular DNA aptamers, with their dramatically enhanced biological and structural stability, hold great potential as new-generation DNA-based anticoagulants. However, the functional selection of circular aptamers and large-scale synthesis of them remains a substantial challenge.

FAP-targeted radioligand therapy with Ga/Lu-DOTA-2P(FAPI) enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy.

Background: Fibroblast activation protein (FAP)-targeted radioligand therapy, with immunomodulatory effects, has shown efficacy in both preclinical and clinical studies. We recently reported on a novel dimeric FAP-targeting radiopharmaceutical, Ga/Lu-DOTA-2P(FAPI), which demonstrated increased tumor uptake and prolonged retention in various cancers. However, further exploration is required to understand the therapeutic efficacy and underlying mechanisms of combining Ga/Lu-DOTA-2P(FAPI) radioligand therapy with PD-1/PD-L1 immunotherapy.

Improved Method for the Calculation of the Air Film Thickness of an Air Cushion Belt Conveyor.

The air film thickness is an important parameter of an air cushion belt conveyor, which directly affects the compressed air supply power and operating resistance of the system. Therefore, it is important to calculate the bottom thickness of the gas film accurately in the design stage. A calculation method for the thickness of a conveyor air cushion was derived based on the mathematical model of the air cushion flow field for a multi row uniformly distributed air cushion structure.

Work Reward Moderates the Association Between Work Effect and Workplace Violence Among Medical Staff in China.

Purpose: Workplace violence (WPV) against healthcare workers is a significant public health issue in China and globally. Although the effort-reward imbalance theory claimed that work rewards may moderate the relationship between work effort and WPV, the quantitative evidence is limited. This study aimed to examine if work reward could moderate the associations between work effort and WPV against medical staff based on the effort-reward imbalance theory.

Ga-FAPI-46 PET/CT in the evaluation of gliomas: comparison with F-FDG PET/CT and contrast-enhanced MRI.

This study compared Ga-FAPI-46 PET/CT, F-fluorodeoxyglucose (FDG) PET/CT, and contrast-enhanced MRI (CE-MRI) for glioma imaging, classification, and recurrence detection and explored PET parameters and molecular pathological profiles. Between June 2020 and June 2024, we prospectively enrolled patients with space-occupying lesions in the brain or previously treated gliomas. All patients underwent sequential CE-MRI, Ga-FAPI-46, and F-FDG PET/CT.

Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province.

Osteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly.

68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer.

BACKGROUNDConsidering that trophoblast cell-surface antigen 2 (Trop2) is overexpressed in a wide range of human epithelial cancers, it presents an attractive target for diagnosis and treatment of multiple types of cancer. Herein, we have developed a Trop2-specific radiotracer, 68Ga-MY6349, and present a prospective, investigator-initiated trial to explore the clinical value of 68Ga-MY6349 PET/CT.METHODSIn this translational study, 90 patients with 15 types of cancer who underwent 68Ga-MY6349 PET/CT were enrolled prospectively.

Preparation of hydrophilic PVDF membranes through in situ assembly of phytate-polyethyleneimine-Fe for efficient separation of herbal volatile oil from oily water.

In the realm of oil-water separation technologies, membrane-based separation emerges as an efficacious approach. Nevertheless, crafting a hydrophilic membrane capable of effectively segregating herbal volatile oil remains a formidable challenge. Our study introduces a facile in situ assembly strategy for fabricating a double-crosslinked composite coating comprising phytate (PA)-polyethyleneimine (PEI) polyelectrolyte complexes and PA-Fe⁺ assemblies.

Enantioselective effects of chiral profenofos on the conformation for human serum albumin.

Profenofos, as a typical chiral organophosphorus pesticide, can cause various environmental problems and even endanger human health when used in excess. The toxicity of chiral profenofos was investigated through multispectral analysis, molecular docking, and density functional theory (DFT), employing human serum albumin (HSA) as the model protein. Fluorescence titration and lifetime measurements demonstrated that the interaction between chiral profenofos and HSA involves static quenching.