SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors.

Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6 inhibitors) can significantly extend tumor response in patients with metastatic luminal A breast cancer, yet intrinsic and acquired resistance remains a prevalent issue. Understanding the molecular features of CDK4/6 inhibitor sensitivity and the potential efficacy of their combination with novel targeted cell death inducers may lead to improved patient outcomes. Herein, we demonstrate that ferroptosis, a form of regulated cell death driven by iron-dependent phospholipid peroxidation, partly underpins the efficacy of CDK4/6 inhibitors.

Derived from fangchinoline, LYY-35 exhibits an inhibiting effect on human NSCLC cancer A549 cells.

Although fangchinoline has been widely used as an adjunct therapy for a variety of inflammatory and cancerous diseases, its mechanism of action on tumor cells remains unclear. Fangchinoline derivative LYY-35 reduced the number of A549 cells, deformed cell morphology and increased cell debris. Cell viability was significantly reduced, while the same concentration of LYY-35 had little effect on BEAS-2B viability of normal lung epithelial cells.

Research on Mechanical and Shrinkage Characteristics of a Resource-Based Cement Solid-Waste Concrete.

Recycling of multi-source solid waste is of great benefit to energy conservation and environmental governance. In this paper, a new type of environmental protection concrete for railway accessory facilities was prepared from silicon-manganese slag, steel slag, fly ash and recycled macadam. Seven kinds of concrete with different mix proportions were designed.

The upregulation of immune checkpoints after photodynamic therapy reducing immune effect for treating breast cancer.

The immune effect induced by photodynamic therapy (PDT) has a limited effect on breast tumor. This study hypothesized that suppressive immune checkpoints on T cells might upregulate after PDT, which may reduce the antitumor effect of PDT for treating breast tumor. This study explored the alteration of immune checkpoint for the first time.

Investigating on the Pavement Performance of Multi-Source Solid Wastes by Cement and Fly Ash.

In order to advance the utilization rate of multi-source solid wastes in the Ningxia region of China, 16 groups of pavement base mixtures were designed with cement and fly ash (FA) as binders, steel slag (SS), silicon manganese slag (SMS), and recycled crushed stone (RCS) as composite aggregates. The evolution laws of mechanical and frost resistance properties of the mixture were investigated by unconfined compressive strength (UCS), indirect tensile strength (ITS), freeze-thaw (FT), and ultrasonic detection tests. Then, the strength formation mechanisms were revealed by microscopic characterization technology.

Comprehensive analysis of the immunogenic cell death-related signature for predicting prognosis and immunotherapy efficiency in patients with lung adenocarcinoma.

Background: Although immunotherapy has been considered as a potent strategy for lung adenocarcinoma (LUAD), only a small part of patients was served as potentially clinical benefiters. Immunogenic cell death (ICD), a type of regulated cell death (RCD), which enable to reshape the tumor immune microenvironment and contribute to the immunotherapy efficiency. Developing a novel ICD-based signature may be a potential strategy to differentiate prognosis of patients with LUAD and predict efficacy of immunotherapy.

Management of a rare giant cell tumor of the distal fibula: A case report.

Background: Aggressive giant cell tumor of the distal fibula is so rare that no consensus on a surgical strategy has been reached. Thus, an appropriate treatment strategy is still important to discuss.

Case Summary: A 61-year-old man who had been experiencing progressive swelling of the left lateral malleolus accompanied by pain for half a year was presented at our hospital.

Downregulation of miR-21 is Involved in the Pathogenesis of Infection-Induced Preterm Birth by Targeting NF-κB.

Infection-induced preterm birth (PTB) is contributing to the main factors of increased maternal and fetal morbidity and mortality. Infections and inflammation are often accompanied by histologic chorioamnionitis. Recently, several studies have uncovered that miR-21 and NF-κB are associated with pathological processes of pregnant women.

Assessment on Changes of Ecosystem Carbon Storage in Reservoir Area due to Hydroproject.

Hydropower offers significant value for global carbon peak and carbon neutrality. However, the construction of hydropower stations leads to significant changes in land use and cover structure in reservoir areas, which affect ecosystem services including carbon balance. Furthermore, the development and operation of hydropower project require vast investment.

Aberrantly up-regulated miR-142-3p inhibited the proliferation and invasion of trophoblast cells by regulating FOXM1.

Introduction: Preeclampsia is one of the main causes of morbidity and mortality in pregnant women and mothers. Numerous studies showed that microRNAs (miRNAs) played important roles in the occurrence and development of preeclampsia. However, the regulation of microRNA-142-3p (miR-142-3p) in preeclampsia has not been clarified.

A new palliative treatment for blastic plasmacytoid dendritic cell neoplasm: a case report and review of the literature.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy that derives from plasmacytoid dendritic cells. The cancer is characterized by aggressive development and dismal prognosis, and due to limited prospective study, there is currently no established standard treatment. In this study, the case of a 77-year old female patient with BPDCN, who presented with a cutaneous lesion on the right of her face, is described.

Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green.

Background: Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green.

Characteristics of temperature changes in photothermal therapy induced by combined application of indocyanine green and laser.

Photothermal therapy, a type of laser application, has the ability to eradicate tumor cells by a local thermal effect and elicit a tumor specific immune response. Indocyanine green (ICG), a photosensitizer, can effectively elevate the local temperature by absorbing energy from the laser. The present study aimed to investigate the characteristics of temperature changes during photothermal therapy with an infrared thermometer in an ICG solution and in tumor-bearing mice treated with a combination of laser and ICG.

The role and significance of endomorphin-1 and μ-opioid receptor in rats with endometriosis.

Endomorphin-1 (EM-1) was reported to have very high affinity and selectivity for μ-opioid receptor (MOR). However, it remained unclear whether EM-1 and MOR were involved in the pathologies of endometriosis resulting in reduced fertility. In this study, RT-PCR, radioimmunoassay, immunohistochemistry, and Western blot were used, respectively.

[Catalytic degradation of naphthalene by CuO (-CeO2)/Al2O3].

Three catalysts CuO/Al2O3, CeO2/Al2O3 and CuO-CeO2/Al2O3 were prepared by the impregnation method. The textural and structural properties of the synthesized catalysts were characterized by N2 adsorption/desorption, SEM and XRD, and the effect of active ingredients, flow rate and reaction temperature on catalytic degradation of naphthalene (NaP) were investigated in fixed-bed reactor. The experimental results show that the prepared 18% CeO2/Al2O3 has a low catalytic activity of NaP.