Publications by authors named "Long S Le"
produce amyloid proteins called curli that are the major proteinaceous component of biofilms. Amyloids are also produced by humans and are associated with diseases such as Alzheimer's. During the multistep process of amyloid formation, monomeric subunits form oligomers, protofibrils, and finally mature fibrils.
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- The study explores how the immune system affects gut bacteria, specifically how STAT2-dependent type I interferon signaling creates an environment that helps harmful bacteria like S. Typhimurium thrive.
- In experiments with Stat2-/- mice (lacking STAT2), the researchers found these mice had less bacterial presence and different inflammatory responses compared to wild-type mice, despite both groups showing similar inflammation levels.
- The findings suggest that without STAT2, there is less disruption in the gut's oxygen levels and a more balanced microbiota, indicating that STAT2 plays a crucial role in fostering conditions that favor pathogenic bacteria during infections.