Publications by authors named "Long Kaihua"
Article Synopsis
- Chronic atrophic gastritis, precancerous lesions, and gastric cancer pose serious health risks, prompting the exploration of traditional Chinese medicine (TCM) as an effective treatment option.
- The study aims to provide a comprehensive overview of TCM's research, focusing on its effects and molecular mechanisms when treating chronic gastritis, precancerous lesions, and gastric cancer.
- By reviewing ancient texts and modern studies, the research analyzed 174 articles, detailing 20 TCM formulas, 14 herbs, and 50 active ingredients, and summarizing their effects and mechanisms to support clinical application.
Article Synopsis
- Temozolomide (TMZ) is a common medication for melanoma, but it has high toxicity and limited effectiveness; combining it with traditional Chinese medicine (SLE) can improve outcomes by reducing side effects.
- The study aimed to investigate how the SLE formula enhances the effects of TMZ by targeting the STAT3 signaling pathway, which plays a key role in melanoma development.
- Results showed that the SLE/TMZ combination not only reduced melanoma cell growth and induced cell death but also positively influenced immune response in mice while effectively inhibiting STAT3 and its related factors.
Background: Immobilized proteins hold promise as the basic units that have enabled a broad range of analytical applications within chemical measurement science. As yet, the co-immobilization of diverse proteins at precise ratio and whether they give rise to improved analytical performance remain challengeable. Herein, we utilized a circularly permuted HaloTag (cpHaloTag) to achieve the co-immobilization of two proteins at precise ratio, which was applied in developing a chromatographic method with improved specificity for pursuing dual-target compounds.
View Article and Find Full Text PDFFunctional protein immobilization forms the basis for bio-detections. A series of one-point, site-specific immobilization methods have been developed, however, it still remains as a challenge how to avoid the proteins to move in all directions as well as conveniently regenerate the bio-devices. Herein, we have developed a bivalent affinity binding-inspired method for PPARγ immobilization using DNA aptamer and nickel-nitrilotriacetic acid (Ni-NTA) chelation.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) has been a highly common and pathological disease worldwide, while current therapeutic regimens have limitations. , a common herbal medicine in Asia, has been documented to exert potential therapeutic effects on HCC in ancient medicine clinical practice. However, the molecular mechanism underlying its inhibitory effects on HCC requires further investigation.
View Article and Find Full Text PDFEthnopharmacological Relevance: Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Lamiaceae, Danshen in Chinese) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong Hort., Apiaceae, Chuanxiong in Chinese) both are important traditional Chinese medicine (TCM) for activating blood and eliminating stasis.
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